IndraLab

Statements


EGF leads to the phosphorylation of RAF1 on serine. 3 / 3
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"Inhibition of Pak reduced the Ser (338) phosphorylation of c-Raf in response to both PDGF and EGF; however, in the case of EGF, the reduction in Ser (338) phosphorylation was not accompanied by a significant decrease in c-Raf activity."

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"In vivo EGF treatment rapidly stimulated phosphorylation of RAF-1 exclusively on serine residues."

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"EGF induced RAF-1 serine phosphorylation required the intrinsic tyrosine kinase activity of the EGF receptor but was independent of EGF receptor self phosphorylation and of ligand induced receptor internalization."