IndraLab

Statements

EGF leads to the phosphorylation of RAF1 on S338. 5 / 5
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"While little or no effect was seen in cells treated with PLX4032, RGS treatment completely inhibited EGF-induced c-RAF Ser338 phosphorylation ( xref )."
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"Moreover, the Ser338 phosphorylation of Raf-1 induced by epidermal growth factor (EGF) stimulation is impaired by an inhibitor of phosphoinositide 3-kinase (PI 3-kinase) 17 suggesting that PAK2 mediat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Pharmacological inhibitors of PI 3-kinase also blocked both activation and Ser338 phosphorylation of Raf-1 induced by epidermal growth factor (EGF)."
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"On the other hand, co-expression of constitutively active PAK5 caused a very strong phosphorylation of cytoplasmic Raf-1 on serine 338 that was not further stimulated by addition of EGF (compare lanes 11 and 12), indicating that PAK5 could access Raf-1 in this fraction."
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"Moreover, simultaneous knockdown of both PAK2 and PLA2G7 did not further attenuate EGF-stimulated S338-phosphorylation of RAF1 or phosphorylation of MEK and ERK (Figure 7F, right three lanes), which further support that PLA2G7 and PAK2 exist in the same signal pathway to regulate RAF1 activation."
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