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EGF leads to the phosphorylation of RAF1 on S338. 12 / 12
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"On the other hand, co-expression of constitutively active PAK5 caused a very strong phosphorylation of cytoplasmic Raf-1 on serine 338 that was not further stimulated by addition of EGF (compare lanes 11 and 12), indicating that PAK5 could access Raf-1 in this fraction."
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"We showed that Raf-1 S338 is strongly phosphorylated in response to EGF during the M phase."
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"We also showed that EGF-induced Raf-1 S338 phosphorylation was inhibited in both interphase and mitosis when Cos7 cells were treated with AG1478 to inhibit EGFR activation ( SI Fig. 2F )."
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"Pharmacological inhibitors of PI 3-kinase also blocked both activation and Ser338 phosphorylation of Raf-1 induced by epidermal growth factor (EGF)."
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"In contrast to the non-treated controls, W-13 and/or EGF did not further increase Ser338 phosphorylation of Raf-1, suggesting a potential CaM-dependent involvement of EGFR in K-RasG12V mediated Raf-1 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, simultaneous knockdown of both PAK2 and PLA2G7 did not further attenuate EGF-stimulated S338-phosphorylation of RAF1 or phosphorylation of MEK and ERK (Figure 7F, right three lanes), which further support that PLA2G7 and PAK2 exist in the same signal pathway to regulate RAF1 activation."
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"While little or no effect was seen in cells treated with PLX4032, RGS treatment completely inhibited EGF-induced c-RAF Ser338 phosphorylation ( xref )."
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"Interestingly, Raf-1 S338 was phosphorylated following EGF stimulation during mitosis at a similar level to the interphase ( Fig. 9 A & B)."
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"We showed that Raf-1 was well expressed in mitosis and EGF stimulated Raf-1 S338 phosphorylation in the M phase to a level similar to the interphase in both Cos7 and CHO-EGFR cells ( SI Fig. 2D )."
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"We also examined EGF-induced Raf-1 S338 phosphorylation in Cos7 and CHO-EGFR cells."
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"Moreover, the Ser338 phosphorylation of Raf-1 induced by epidermal growth factor (EGF) stimulation is impaired by an inhibitor of phosphoinositide 3-kinase (PI 3-kinase) 17 suggesting that PAK2 mediat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We showed that Raf-1 was well expressed in mitosis and EGF stimulated Raf-1 S338 phosphorylation in the M phase to a level similar to the interphase in both Cos7 and CHO-EGFR cells ( SI Fig. 2D )."
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