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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
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SRC leads to the phosphorylation of EGFR. 9 / 198
| 1 27 78 83
reach
"Down-regulation of Lyn kinase, but not Src kinase, by specific small interfering RNA mitigated LPA induced MMP activation, proHB-EGF shedding, and EGFR phosphorylation."
sparser
"There are two major mechanisms of EGFR transactivation: (1) stimulation of metalloproteases which generate peptide EGFR ligands from their membrane-bound precursors, and (2) activation by reactive oxygen species of non-receptor tyrosine kinase Src, which phosphorylates intracellular domain of EGFR."
rlimsp
"As a consequence, c-Src phosphorylated EGFR, promoting the invasion and metastasis of HCCs."
sparser
"Activated c-Src then phosphorylates the EGFR, which leads to increased association of Shc and Grb2/Sos with the EGFR, and subsequent activation of Ras, Raf-1 and MEK-1/2 [29] ."
rlimsp
"Tyrosine (Tyr) 845 of ErbB1 is phosphorylated by Src and has been implicated in control of malignant behavior."
sparser
"In the present study, we found that the Src-dependent phosphorylation of EGFR induced by SCI occurred only in neurons, not in astrocytes."
rlimsp
"Finally, experiments are presented demonstrating that, upon stimulation of GPCR, activated Pyk2 forms a complex with Src, which in turn phosphorylates EGFR directly."
rlimsp
"In particular, we show that ROS are responsible for the redox-mediated activation of Src that trans-phosphorylates epidermal growth factor receptor (EGFR) in a ligand-independent manner."
sparser
"O 3 exposure and induction of Src-​dependent phosphorylation of the EGFR in HBEC."
SRC phosphorylates EGFR on Y869. 10 / 174
1 3 1 2 | 47 51 65
reach
"In XREF_BIBR, experimental results have shown that EGFR activates SRC and is phosphorylated by SRC on Tyr 845, indicating bi-directional relation between EGFR and SRC."
reach
"Since we observed phosphorylation of EGFR on tyrosine 845 in response to treatment with PGE 2, we next examined the possible contribution of Src, which is known to phosphorylate EGFR at tyrosine 845 and previously shown to transactivate EGFR in response to PGE 2 in colorectal cancer cells."
sparser
"Previously, it was reported that in ER-positive breast cancer T47D cells, estrogen-induced Src activation and Src-dependent phosphorylation of EGFR-Y845 recruits STAT5 as a downstream effector of phosphorylated EGFR-Y845 to induce c-Myc and Cyclin D1 expression ( xref )."
rlimsp
"Here, we used a NIH 3T3 cell transformation system to underscore the critical involvement of signaling through Src, orchestrated by the Src phosphorylation site on EGFR (Y845), which appears crucial in linking mutant EGFRs to oncogenesis and constitutive activation of specific signaling pathways."
reach
"Subsequently, these investigators identified and validated that EGFR was indeed phosphorylated by c-Src at Y845 and Y1101."
reach
"EGFR (Tyr845) phosphorylation is mediated primarily by Src kinase."
reach
"c-Src phosphorylates epidermal growth factor receptor on tyrosine 845."
rlimsp
"These collective findings indicate that EGFR transactivation by ATP is critically dependent on initial activation of Src, which in turn phosphorylates EGFR at Y845 and activates ADAM17 to promote ligand-dependent EGFR autophosphorylation."
rlimsp
"For the past eighteen years or so, since the initial discovery of the Src phosphorylation of EGFR on Y845, much progress has been made in the recognition that Y845 phosphorylation takes place in a variety of cancerous and normal physiological cell contexts, as well as in the understanding that Y845 phosphorylation plays pivotal roles in these cellular contexts (Figure 2)."
biopax:netpath
No evidence text available
SRC phosphorylates EGFR on tyrosine. 10 / 33
| 7 12 14
reach
"In COS-7 cells, Src was reported to induce EGFR tyrosine phosphorylation after stimulation of the G i -coupled LPA and alpha 2A -adrenergic receptors or overexpression of Gbetagamma subunits, independently of the intrinsic kinase activity of EGFR [XREF_BIBR]."
reach
"This paper reports that CDCP1 forms a ternary complex with Src and the EGFR, and that this complex mediates Src activation and Src dependent tyrosine phosphorylation of CDCP1 and EGFR (i.e., EGFR transactivation)."
sparser
"While c-Src induces phosphorylation of the EGFR at critical activating tyrosine residues ( Biscardi et al. 1999; Tice et al. 1999 ), the suppressing effect of Fyn on EGFR activation is not due to incr[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
sparser
"Two well-known mechanisms of EGFR transactivation are: (1) extracellular cleavage of membrane-bound EGFR ligands by activated MMPs or ADAMs that can then engage the receptor, and (2) intracellular phosphorylation of EGFR tyrosine residues by Src kinases [ xref , xref ]."
sparser
"Biscardi and colleagues found that Src was able to phosphorylate EGFR at two unique tyrosine residues, distinct from the autophosphorylation sites, to activate EGFR, in association with the activation[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
rlimsp
"We show that Src kinases are critical for activation of Pyk2 in response to GPCR-stimulation and that Pyk2 and Src are essential for GPCR-induced tyrosine phosphorylation of EGFR."
reach
"Although the functional connection between Src and the EGFR is still unclear, EGFR tyrosine phosphorylation by Src was shown to be crucial for EGF induced and LPA induced mitogenic responses [XREF_BIBR]."
reach
"Basal breast cancer cells are characterized by elevated tyrosine phosphorylation of Met, Lyn, EphA2, epidermal growth factor receptor (EGFR), and FAK, and Src family kinase (SFK) substrates such as p130Cas."
sparser
"The protein tyrosine kinase c-Src can directly phosphorylate Tyr residues in the kinase domain HER2 [ xref , xref ] and the cytoplasmic tail of EGFR [ xref ], allowing the formation of stable homo- or heterocomplexes with other receptors or the binding of scaffold proteins and the activation of signal transduction."
rlimsp
"Later, Wasilenko et al. [39] made the first demonstration that Src is capable of phosphorylating EGFR on unknown tyrosine residue(s)."
SRC phosphorylates EGFR on Y1125. 9 / 21
1 3 1 4 | 2 4 5
signor
"The c-terminal autophosphorylation domain of egfr was extensively phosphorylated by c-src./These studies revealed that y1086 was phosphorylated to a significantly higher extent by c-src than by egfr. Additionally, y1101 was identified as a unique c-src phosphorylation site"
rlimsp
"As a consequence, c-Src phosphorylated EGFR at Y1101 and Y845, promoting the invasion and metastasis of HCCs."
biopax:phosphositeplus
No evidence text available
hprd
No evidence text available
reach
"Subsequently, these investigators identified and validated that EGFR was indeed phosphorylated by c-Src at Y845 and Y1101."
reach
"However, inhibition of Src tyrosine kinase activity inhibiting the maximal activation of EGFR by preventing the phosphorylation of EGFR at Y845 and Y1101."
reach
"Src phosphorylates EGFR in C-terminal (Y1101) and catalytic domains (Y845), and phosphorylation of Y845 by Src promotes EGFR mediated DNA synthesis [XREF_BIBR]."
biopax:netpath
No evidence text available
reach
"As a consequence, c-Src phosphorylated EGFR at Y1101 and Y845, promoting the invasion and metastasis of HCCs."
SRC phosphorylates EGFR on Y1197. 9 / 9
1 | 2 2 4
rlimsp
"It is well known that Src can phosphorylate EGFR on Y845, but it has been reported that Src phosphorylation on this residue does not affect EGFR autokinase activity [13], suggesting that EGFR Y1173 phosphorylation should not be decreased by Src inhibition, unless the anti-Src agents have cross-reactivity with EGFR."
reach
"Nevertheless, it is an alternative way of EGFR activation being related to oncogenic pathways; activated c-Src phosphorylates the EGFR at Y1173 [XREF_BIBR]."
sparser
"Within this complex beta1 integrin became activated thereby inducing a c-Src-dependent EGFR phosphorylation at Y1086 and Y1173 EGF-independent residues."
sparser
"Nevertheless, it is an alternative way of EGFR activation being related to oncogenic pathways; activated c-Src phosphorylates the EGFR at Y1173 [ xref ]."
biopax:reactome
No evidence text available
reach
"It is well known that Src can phosphorylate EGFR on Y845, but it has been reported that Src phosphorylation on this residue does not affect EGFR autokinase activity [XREF_BIBR], suggesting that EGFR Y1173 phosphorylation should not be decreased by Src inhibition, unless the anti-Src agents have cross-reactivity with EGFR."
reach
"However, it has been reported that Src mediated phosphorylation on EGFR Y845 does not affect EGFR autokinase activity [XREF_BIBR], suggesting that EGFR Y1173 phosphorylation should not be decreased by Src inhibition, unless the inhibitors have cross-reactivity with the EGFR."
rlimsp
"However, it has been reported that Src-mediated phosphorylation on EGFR Y845 does not affect EGFR autokinase activity [13], suggesting that EGFR Y1173 phosphorylation should not be decreased by Src inhibition, unless the inhibitors have cross-reactivity with the EGFR."
reach
"A list of proteins most negatively correlated with phenotype includes all measurements of EGFR phosphorylated at tyrosine 1173 as well as Src, which has been shown to phosphorylate EGFR tyrosine 1173."
SRC phosphorylates EGFR on Y1092. 6 / 6
1 4 | 1
hprd
No evidence text available
reach
"These studies suggest that Src kinase can directly phosphorylate EGFR (Y1068)."
biopax:reactome
No evidence text available
hprd
No evidence text available
hprd
No evidence text available
hprd
No evidence text available
SRC phosphorylates EGFR on Y998. 5 / 5
5 |
hprd
No evidence text available
hprd
No evidence text available
hprd
No evidence text available
hprd
No evidence text available
hprd
No evidence text available
SRC phosphorylates EGFR on Y944. 5 / 5
1 2 | 1 1
hprd
No evidence text available
hprd
No evidence text available
sparser
"Stover et al [ xref ] showed that activated Src can phosphorylate HER1 at Tyr 891 and Tyr 920 in vitro , and that these sites can mediate binding of the SH2 domains of phosphatidyl inositol-3 kinase (PI-3K) and Src itself."
reach
"Stover et al [XREF_BIBR] showed that activated Src can phosphorylate HER1 at Tyr 891 and Tyr 920 in vitro, and that these sites can mediate binding of the SH2 domains of phosphatidyl inositol-3 kinase (PI-3K) and Src itself."
biopax:phosphositeplus
No evidence text available
Kinase-active SRC phosphorylates EGFR on Y869. 5 / 5
5 |
bel
"As Tyr-845 is a c-Src target.; phosphorylation of Tyr-845 in the EGFR"
bel
"When co-overexpressed, the epidermal growth factor receptor (EGFR) and c-Src cooperate to cause synergistic increases in EGF-induced DNA synthesis, soft agar colony growth, and tumor formation in nude mice. This synergy is dependent upon c-Src-mediated phosphorylation of a unique tyrosine on the EGFR, namely, tyrosine 845 (Y845). "
bel
"Since Tyr-845 of EGFR is a known Src target, we next determined whether hyperphosphorylation of this site under cigarette smoke was due to Src kinase activation."
bel
"TGF-beta1-stimulated PAI-1 expression, moreover, was preceded by EGFR phosphorylation on Y845 (a src kinase target residue) and required pp60(c-src) activity."
bel
"In this study, we demonstrated that c-Src-dependent phosphorylation of tyrosine 845 (Tyr 845) on EGFR was required for DNA synthesis induced by the G protein-coupled agonists, endothelin (ET) and lysophosphatidic acid (LPA), and the cytokine, growth hormone (GH), in murine fibroblast and breast cancer model systems. "
SRC phosphorylates EGFR on Y1110. 5 / 5
1 1 1 | 1 1
rlimsp
"These studies revealed that Y1086 was phosphorylated to a significantly higher extent by c-src than by EGFR."
biopax:reactome
No evidence text available
sparser
"Within this complex beta1 integrin became activated thereby inducing a c-Src-dependent EGFR phosphorylation at Y 1086 and Y 1173 EGF-independent residues."
biopax:phosphositeplus
No evidence text available
signor
"The c-terminal autophosphorylation domain of egfr was extensively phosphorylated by c-src./These studies revealed that y1086 was phosphorylated to a significantly higher extent by c-src than by egfr. Additionally, y1101 was identified as a unique c-src phosphorylation site."
SRC phosphorylates EGFR on Y915. 3 / 3
1 2 |
hprd
No evidence text available
hprd
No evidence text available
biopax:phosphositeplus
No evidence text available
SRC phosphorylates EGFR on Y1172. 3 / 3
1 1 | 1
sparser
"For ß1 integrin-coupled EGFR activation, adhesion-dependent Src activation seems to be crucial [17] , and active Src, unlike soluble EGF, phosphorylates EGFR at tyrosine (Y) 845 and not at one of the[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
signor
"Revealed that peptides derived from egfr residues y992, y1086, y1101, and y1148 bound directly to the sh2 domain of c-src (figure 8c). These experiments demonstrate that a specific subset of egfr receptor c-src phosphorylation sites are also ligands for the sh2 domain of c-src.Cellular src functions as a co-transducer of transmembrane signals emanating from a variety of growth factor receptors, including egfr"
biopax:reactome
No evidence text available
SRC phosphorylates EGFR on Y1016. 3 / 3
1 1 1 |
biopax:phosphositeplus
No evidence text available
biopax:reactome
No evidence text available
signor
"The c-terminal autophosphorylation domain of egfr was extensively phosphorylated by c-src./These studies revealed that y1086 was phosphorylated to a significantly higher extent by c-src than by egfr. Additionally, y1101 was identified as a unique c-src phosphorylation site"
SRC phosphorylates EGFR on Y891. 2 / 2
| 1 1
sparser
"Stover et al [ xref ] showed that activated Src can phosphorylate HER1 at Tyr 891 and Tyr 920 in vitro , and that these sites can mediate binding of the SH2 domains of phosphatidyl inositol-3 kinase (PI-3K) and Src itself."
reach
"Stover et al [XREF_BIBR] showed that activated Src can phosphorylate HER1 at Tyr 891 and Tyr 920 in vitro, and that these sites can mediate binding of the SH2 domains of phosphatidyl inositol-3 kinase (PI-3K) and Src itself."
Kinase-active SRC phosphorylates EGFR on Y1125. 1 / 1
1 |
bel
"8845374;11983694;10075741"
Kinase-active SRC phosphorylates EGFR on Y944. 1 / 1
1 |
bel
"PhosphoElm data from PMID 15212693"
SRC phosphorylated on Y419 phosphorylates EGFR on Y1197. 1 / 1
1 |
biopax:pid
No evidence text available
SRC phosphorylates EGFR on Y727. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
SRC phosphorylated on Y419 phosphorylates EGFR on Y1092. 1 / 1
1 |
biopax:pid
No evidence text available
SRC phosphorylated on Y419 phosphorylates EGFR on Y1069. 1 / 1
1 |
biopax:pid
No evidence text available
Modified SRC leads to the phosphorylation of EGFR on tyrosine. 1 / 1
| 1
reach
"Overexpression of either a dominant negative Src construct or Csk, a regulatory kinase that inhibits Src function, decreases EGF receptor tyrosine phosphorylation provoked by activation of LPA or alpha2 adrenergic receptors (Luttrell et al. 1997)."
Kinase-active SRC leads to the phosphorylation of EGFR. 1 / 1
1 |
bel
"PTPD1 activates src tyrosine kinase and increases the magnitude and duration of epidermal growth factor (EGF) signaling. EGF receptor phosphorylation and downstream activation of ERK 1/2 and Elk1-dependent gene transcription are enhanced by PTPD1."
SRC phosphorylated on Y419 phosphorylates EGFR on Y869. 1 / 1
1 |
biopax:pid
No evidence text available
SRC phosphorylates EGFR on methionine. 1 / 1
| 1
reach
"Basal breast cancer cells are characterized by elevated tyrosine phosphorylation of Met, Lyn, EphA2, epidermal growth factor receptor (EGFR), and FAK, and Src family kinase (SFK) substrates such as p130Cas."
SRC phosphorylated on Y419 phosphorylates EGFR on Y1172. 1 / 1
1 |
biopax:pid
No evidence text available
SRC phosphorylates EGFR on arginine. 1 / 1
| 1
reach
"Src can also phosphorylate and activate Abl and Arg downstream of EGFR and other growth factor receptors and recent work has shown that removal of Abl or Arg by RNAi prevents invadopodia formation in Src transformed fibroblasts, MDA-MB-231 breast cancer and melanoma cell lines."
Kinase-active SRC phosphorylates EGFR on Y1016. 1 / 1
1 |
bel
"A subset of peptides corresponding to the eight possible tyrosine phosphorylation sites within the EGFR autophosphorylation domain was demonstrated to bind to the SH2 domain of c-src. Those which bound to the SH2 domain included peptides derived from EGFR sequences flanking Y992, Y1086, Y1101, and Y1148. These data indicate that specific EGF receptor c-src phosphorylation sites are also ligands for the SH2 domain of c-src. "
SRC phosphorylates EGFR on Y764. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
SRC phosphorylated on Y419 phosphorylates EGFR on Y1016. 1 / 1
1 |
biopax:pid
No evidence text available
SRC phosphorylated on Y419 phosphorylates EGFR on Y1110. 1 / 1
1 |
biopax:pid
No evidence text available
SRC phosphorylates EGFR on Y1069. 1 / 1
1 |
biopax:reactome
No evidence text available