IndraLab

Statements

SRC phosphorylates EGFR on Y1110. 12 / 12
1 1 1 | 2 2 5
rlimsp
"This suggests that, although Tyr-1086 provides a potential channel for phosphorylation of EGFR by c-Src, the sequence of this phosphosite limits the efficiency of such phosphorylation."
30012625
reach
"The GPCR mediated activation of Src is capable to phosphorylate tyrosine residues of EGFR at Y845 in the activation loop and at Y1110 and in the C-terminal region of EGFR."
28705643
signor
"The c-terminal autophosphorylation domain of egfr was extensively phosphorylated by c-src./These studies revealed that y1086 was phosphorylated to a significantly higher extent by c-src than by egfr. Additionally, y1101 was identified as a unique c-src phosphorylation site."
8845374
rlimsp
"In one such cell line, SUM229, inhibiting c-Src kinase activity with either a dominant-negative c-Src or a c-Src TKI decreased EGFR phosphorylation on Tyr(845), Tyr(992), and Tyr(1086) in the presence of EGFR TKIs."
18451158
reach
"It was shown that Src induces EGFR phosphorylation at Y1110."
28705643
rlimsp
"(D) Heat map showing the effect of single amino acid substitutions on the phosphorylation level of the EGFR Tyr-1086 phosphosite relative to wild type upon phosphorylation by c-Src, as measured by bacterial surface display and deep sequencing."
30012625
sparser
"Within this complex beta1 integrin became activated thereby inducing a c-Src-dependent EGFR phosphorylation at Y 1086 and Y 1173 EGF-independent residues."
27713116
rlimsp
"A recent study showing Src kinase which normally phosphorylates EGFR at tyrosyl 1173, could mediate phosphorylation of Tyr1110 in EGFR, and regulate mitogenic signalling [31]."
29644001
biopax:phosphositeplus
No evidence text available
rlimsp
"These studies revealed that Y1086 was phosphorylated to a significantly higher extent by c-src than by EGFR."
8845374
sparser
"It was shown that Src induces EGFR phosphorylation at Y1110."
28705643
biopax:reactome
No evidence text available