IndraLab

Statements

SRC phosphorylates EGFR on Y1125. 24 / 25
3 1 1 4 3 | 6 4 2
rlimsp
"As a consequence, c-Src phosphorylated EGFR at Y1101 and Y845, promoting the invasion and metastasis of HCCs."
25958313
reach
"As a consequence, c-Src phosphorylated EGFR at Y1101 and Y845, promoting the invasion and metastasis of HCCs."
25958313
sparser
"When phosphorylated at Tyr 418 , c-Src can phosphorylate EGFR at Tyr 845 and Tyr 1101 and thereby regulate EGFR functions and tumor progression ( xref )."
23873690
sparser
"Taking EGFR as an example in ERBB, phosphorylation of EGFR at Tyr845 and Tyr1101 directly by c-SRC helps EGFR to retain strong activity [ xref ]."
26849234
biopax:phosphositeplus
No evidence text available
reach
"Src phosphorylates EGFR in C-terminal (Y1101) and catalytic domains (Y845), and phosphorylation of Y845 by Src promotes EGFR mediated DNA synthesis [XREF_BIBR]."
19275932
phosphoelm
No evidence text available
8845374
hprd
No evidence text available
10075741
sparser
"Subsequently, these investigators identified and validated that EGFR was indeed phosphorylated by c-Src at Y845 and Y1101."
22430206
biopax:netpath
No evidence text available
9990038
phosphoelm
No evidence text available
10075741
reach
"Subsequently, these investigators identified and validated that EGFR was indeed phosphorylated by c-Src at Y845 and Y1101."
22430206
phosphoelm
No evidence text available
11983694
rlimsp
"These studies revealed that Y1086 was phosphorylated to a significantly higher extent by c-src than by EGFR. Additionally, Y1101 was identified as a unique c-src phosphorylation site."
8845374
reach
"When phosphorylated at Tyr 418, c-Src can phosphorylate EGFR at Tyr 845 and Tyr 1101 and thereby regulate EGFR functions and tumor progression."
23873690
hprd
No evidence text available
8845374
hprd
No evidence text available
11983694
biopax:netpath
No evidence text available
10075741
signor
"The c-terminal autophosphorylation domain of egfr was extensively phosphorylated by c-src./These studies revealed that y1086 was phosphorylated to a significantly higher extent by c-src than by egfr. Additionally, y1101 was identified as a unique c-src phosphorylation site"
8845374
reach
"For example, in response to EGFR activation, Src becomes activated and subsequently phosphorylates EGFR on Y845 and Y1101, and enhances its endocytosis [53-55]."
29885323
hprd
No evidence text available
16729043
reach
"However, inhibition of Src tyrosine kinase activity inhibiting the maximal activation of EGFR by preventing the phosphorylation of EGFR at Y845 and Y1101."
25958313
sparser
"As a consequence, c-Src phosphorylated EGFR at Y1101 and Y845, promoting the invasion and metastasis of HCCs."
25958313
biopax:netpath
No evidence text available
7542783