IndraLab

Statements

SRC phosphorylates EGFR on Y1197. 9 / 9
1 | 4 2 2
rlimsp
"It is well known that Src can phosphorylate EGFR on Y845, but it has been reported that Src phosphorylation on this residue does not affect EGFR autokinase activity [13], suggesting that EGFR Y1173 phosphorylation should not be decreased by Src inhibition, unless the anti-Src agents have cross-reactivity with EGFR."
26325669
reach
"Nevertheless, it is an alternative way of EGFR activation being related to oncogenic pathways; activated c-Src phosphorylates the EGFR at Y1173 [XREF_BIBR]."
23449029
sparser
"Within this complex beta1 integrin became activated thereby inducing a c-Src-dependent EGFR phosphorylation at Y1086 and Y1173 EGF-independent residues."
27713116
reach
"However, it has been reported that Src mediated phosphorylation on EGFR Y845 does not affect EGFR autokinase activity [XREF_BIBR], suggesting that EGFR Y1173 phosphorylation should not be decreased by Src inhibition, unless the inhibitors have cross-reactivity with the EGFR."
26325669
sparser
"Nevertheless, it is an alternative way of EGFR activation being related to oncogenic pathways; activated c-Src phosphorylates the EGFR at Y1173 [ xref ]."
23449029
reach
"It is well known that Src can phosphorylate EGFR on Y845, but it has been reported that Src phosphorylation on this residue does not affect EGFR autokinase activity [XREF_BIBR], suggesting that EGFR Y1173 phosphorylation should not be decreased by Src inhibition, unless the anti-Src agents have cross-reactivity with EGFR."
26325669
biopax:reactome
No evidence text available
rlimsp
"However, it has been reported that Src-mediated phosphorylation on EGFR Y845 does not affect EGFR autokinase activity [13], suggesting that EGFR Y1173 phosphorylation should not be decreased by Src inhibition, unless the inhibitors have cross-reactivity with the EGFR."
26325669
reach
"A list of proteins most negatively correlated with phenotype includes all measurements of EGFR phosphorylated at tyrosine 1173 as well as Src, which has been shown to phosphorylate EGFR tyrosine 1173."
17206861