IndraLab

Statements

SMAD3 is modified
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SMAD3 is methylated. 10 / 88
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"Meta-analysis of the association between SMAD3 CpG7 methylation and childhood asthma risk in neonates born to asthmatic mothers was performed by using estimates from each study cohort to compute the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Allele-specific DNA methylation of SMAD3 is regulated based on genetic effects relevant to disease susceptibility."
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"We investigated whether SMAD3 methylation is associated with survival in CRC."
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"Given these findings, the objective of this study was to assess a larger sample to further investigate the relationship between Smad3 gene methylation and pulmonary fibrosis in Uygur PBL patients."
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"In contrast, asthmatic and non-asthmatic children of non-asthmatic mothers did not differ in their SMAD3 methylation levels [ P for interaction (by linear regression) = 0.001; xref ]."
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"In contrast, asthmatic and nonasthmatic children of nonasthmatic mothers did not differ in their SMAD3 methylation levels ( P for interaction [by linear regression] = ."
28011059
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"Linear regression was used to test for an interaction between child and maternal asthma on SMAD3 methylation."
28011059
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"SMAD3 methylation in IIS (n = 60) and in 2 replication cohorts (the Manchester Asthma and Allergy Study [n = 30] and the Childhood Origins of Asthma Study [n = 28]) was analyzed by using bisulfite sequencing or Illumina 450K arrays."
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"Moreover , SMAD3 methylation in IIS neonates with maternal asthma was strongly and positively associated with neonatal production of IL-1β, an innate inflammatory mediator."
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"Smad3 methylation by EZH2 promotes its activation and tumor metastasis."
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Valproic acid affects SMAD3
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Valproic acid methylates SMAD3. 4 / 4
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ctd
No evidence text available
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No evidence text available
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No evidence text available
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No evidence text available
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Histone affects SMAD3
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Histone methylates SMAD3. 3 / 3
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"Yang et al. pointed out that the Salvia miltiorrhiza and Carthamus tinctorius extract (SCE) prevents myocardial fibrosis and adverse remodeling after MI by suppressing histone methylation of the SMAD3 and its transcription in cardiac fibroblasts [XREF_BIBR]."
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"To our knowledge, the relationship between histone methylations of Smad3, both H3K4me3 and H3K36me3, and fibrosis has not yet been reported in heart disease but has been previously investigated, mainly in cancer [ xref ] and fibrosis of other organs [ xref ]."
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"Yang et al. pointed out that the Salvia miltiorrhiza and Carthamus tinctorius extract (SCE) prevents myocardial fibrosis and adverse remodeling after MI by suppressing histone methylation of the SMAD3 and its transcription in cardiac fibroblasts [ xref ]."
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EZH2 affects SMAD3
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EZH2 methylates SMAD3. 3 / 3
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"Smad3 methylation by EZH2 promotes its activation and tumor metastasis."
35085106
reach
"Smad3 methylation by EZH2 promotes its activation and tumor metastasis."
35085106
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"Mechanistically, EZH2-triggered SMAD3 methylation facilitates SMAD3 interaction with its cellular membrane localization molecule (SARA), which in turn sustains SMAD3 phosphorylation by the TGFB receptor."
35085106
CXXC1 affects SMAD3
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CXXC1 methylates SMAD3. 2 / 2
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"Interestingly, lower methylation of CpG sites in SMAD3 , a transcription factor known to directly upregulate miR-21 ( xref ), was also found in the chemotherapy- versus non-chemotherapy treated patients."
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"MSP analysis from 81 ACS samples, 74 SCAD samples and 53 healthy samples, and Sequenom MassARRAY analysis, confirmed that differential CpG methylation of SMAD3 was significantly corrected with the reference results of the HumanMethylation450 array."
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Tert-butyl hydroperoxide methylates SMAD3. 1 / 1
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ctd
No evidence text available
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Methapyrilene affects SMAD3
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Methapyrilene methylates SMAD3. 1 / 1
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ctd
No evidence text available
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Lead diacetate affects SMAD3
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Lead diacetate methylates SMAD3. 1 / 1
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ctd
No evidence text available
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Cyclosporin A affects SMAD3
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Cyclosporin A methylates SMAD3. 1 / 1
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ctd
No evidence text available
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Bisphenol A affects SMAD3
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Bisphenol A methylates SMAD3. 1 / 1
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ctd
No evidence text available
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Benzo[e]pyrene affects SMAD3
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Benzo[e]pyrene methylates SMAD3. 1 / 1
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ctd
No evidence text available
30157460
TGFB affects SMAD3
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Modified TGFB leads to the methylation of SMAD3. 1 / 1
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reach
"Therefore, Smad3 gene hypomethylation may be caused by long-term exposure to allergen sources; an increase in levels of TGF-beta, an upstream factor of Smad3; or interactions between these two factors."
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