A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

SMAD3 is modified
| 50 1
SMAD3 is methylated. 10 / 51
| 50 1
sparser
"Meta-analysis of the association between SMAD3 CpG7 methylation and childhood asthma risk in neonates born to asthmatic mothers was performed by using estimates from each study cohort to compute the[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
sparser
"In contrast, the children of asthmatic mothers who had asthma were almost entirely found among those with high SMAD3 promoter methylation and high IL-1β secretion ( P  = ."
sparser
"Most importantly, the SMAD3 methylation differences detected between asthmatic and nonasthmatic children of asthmatic mothers remained significant ( P  = ."
sparser
"In contrast, the children of asthmatic mothers who developed asthma were almost entirely found among those with high SMAD3 promoter methylation and high IL-1β secretion ( P =0.009 by Fisher’s Exact Test; xref )."
sparser
"The distributions of SMAD3 methylation and log IL-1β production in nonasthmatic and asthmatic children without and with a maternal history of asthma were compared by dividing mean percentage SMAD3 [MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
sparser
"Finally, we asked whether the SMAD3 methylation levels measured at birth in children of asthmatic mothers are associated with risk for childhood asthma in our three cohorts."
sparser
"When the relation between SMAD3 methylation at birth and childhood asthma was examined separately in children with and without maternal asthma, SMAD3 methylation was found to be significantly increased in asthmatic compared to non-asthmatic children of asthmatic mothers ( P =0.005 by Wilcoxon two-sample test)."
sparser
"Given these findings, the objective of this study was to assess a larger sample to further investigate the relationship between Smad3 gene methylation and pulmonary fibrosis in Uygur PBL patients."
sparser
"Correlations of Smad3 gene methylation and Smad3 mRNA expression with the extent of pulmonary fibrosis."
sparser
"Mean SMAD3 methylation levels at birth were 41.3% (95% CI, 35.5% to 47.5%) in nonasthmatic subjects and 47.1% (95% CI, 40.6% to 53.1%) in asthmatic subjects, a difference that did not reach statisti[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
CXXC1 affects SMAD3
| 2
CXXC1 methylates SMAD3. 2 / 2
| 2
sparser
"Interestingly, lower methylation of CpG sites in SMAD3 , a transcription factor known to directly upregulate miR-21 ( xref ), was also found in the chemotherapy- versus non-chemotherapy treated patients."
sparser
"MSP analysis from 81 ACS samples, 74 SCAD samples and 53 healthy samples, and Sequenom MassARRAY analysis, confirmed that differential CpG methylation of SMAD3 was significantly corrected with the reference results of the HumanMethylation450 array."
TGFB affects SMAD3
| 1
Modified TGFB leads to the methylation of SMAD3. 1 / 1
| 1
reach
"Therefore, Smad3 gene hypomethylation may be caused by long-term exposure to allergen sources; an increase in levels of TGF-beta, an upstream factor of Smad3; or interactions between these two factors."