"Meta-analysis of the association between SMAD3 CpG7 methylation and childhood asthma risk in neonates born to asthmatic mothers was performed by using estimates from each study cohort to compute the[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
"In contrast, the children of asthmatic mothers who had asthma were almost entirely found among those with high SMAD3 promoter methylation and high IL-1β secretion ( P = ."
"Most importantly, the SMAD3 methylation differences detected between asthmatic and nonasthmatic children of asthmatic mothers remained significant ( P = ."
"In contrast, the children of asthmatic mothers who developed asthma were almost entirely found among those with high SMAD3 promoter methylation and high IL-1β secretion ( P =0.009 by Fisher’s Exact Test; xref )."
"The distributions of SMAD3 methylation and log IL-1β production in nonasthmatic and asthmatic children without and with a maternal history of asthma were compared by dividing mean percentage SMAD3 [MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
"Finally, we asked whether the SMAD3 methylation levels measured at birth in children of asthmatic mothers are associated with risk for childhood asthma in our three cohorts."
"When the relation between SMAD3 methylation at birth and childhood asthma was examined separately in children with and without maternal asthma, SMAD3 methylation was found to be significantly increased in asthmatic compared to non-asthmatic children of asthmatic mothers ( P =0.005 by Wilcoxon two-sample test)."
"Given these findings, the objective of this study was to assess a larger sample to further investigate the relationship between Smad3 gene methylation and pulmonary fibrosis in Uygur PBL patients."
"Correlations of Smad3 gene methylation and Smad3 mRNA expression with the extent of pulmonary fibrosis."
"Mean SMAD3 methylation levels at birth were 41.3% (95% CI, 35.5% to 47.5%) in nonasthmatic subjects and 47.1% (95% CI, 40.6% to 53.1%) in asthmatic subjects, a difference that did not reach statisti[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"