IndraLab

"Smad3 methylation by EZH2 promotes its activation and tumor metastasis."

"EZH2 triggers SMAD3 methylation to promote the interaction between SMAD3 and its cell membrane locator, maintaining SMAD3 phosphorylation of TGFβ receptors and facilitating breast cancer metastasis. xref EZH2 also induces ribosomal synthesis overactivation and ribosomal DNA instability by silencing PHACTR2-AS1 to accelerate breast cancer metastasis. xref EZH2 induces methylation of lysine K362 in ERG, which is beneficial for DNA binding and increases ERG transcriptional activity, thereby enhancing the invasiveness of ERG fusion prostate cancer. xref , xref EZH2 silences primary cilia genes and activates the Wnt pathway to promote melanoma metastasis. xref "

"SMAD3 methylation mediated by EZH2 promotes SMAD3 phosphorylation by TGF-β receptors and is correlated with hyperactivation of TGF-β/SMAD3 signaling and promotion of EMT and metastasis in breast cancer."

"EZH2 triggers SMAD3 methylation to promote the interaction between SMAD3 and its cell membrane locator, maintaining SMAD3 phosphorylation of TGFβ receptors and facilitating breast cancer metastasis."

"Other studies indicated that increased EZH2 expression abnormally increased SMAD3 methylation, thereby activating SMAD3."