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Histone methylates SMAD3. 3 / 3
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"Yang et al. pointed out that the Salvia miltiorrhiza and Carthamus tinctorius extract (SCE) prevents myocardial fibrosis and adverse remodeling after MI by suppressing histone methylation of the SMAD3 and its transcription in cardiac fibroblasts [XREF_BIBR]."
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"To our knowledge, the relationship between histone methylations of Smad3, both H3K4me3 and H3K36me3, and fibrosis has not yet been reported in heart disease but has been previously investigated, mainly in cancer [ xref ] and fibrosis of other organs [ xref ]."
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"Yang et al. pointed out that the Salvia miltiorrhiza and Carthamus tinctorius extract (SCE) prevents myocardial fibrosis and adverse remodeling after MI by suppressing histone methylation of the SMAD3 and its transcription in cardiac fibroblasts [ xref ]."
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