IndraLab

Statements

USP39 affects ZEB1
| 2
USP39 deubiquitinates ZEB1. 2 / 2
| 2
reach
"Collectively, our findings suggest that the balanced deubiquitination and ubiquitination of ZEB1 by USP39 and TRIM26 represent a novel mechanism for the progression of HCC, and this discovery provides a promising strategy for targeting USP39 or TRIM26 in the treatment of HCC cases with aberrant ZEB1 expression levels."
33649471
reach
"USP39 promotes EMT and inhibits ZEB1 ubiquitination in HCC."
33649471
USP39 affects USP4
| 1
USP39 deubiquitinates USP4. 1 / 1
| 1
reach
"USP39 binds with USP4 via its UBL domain and correspondingly enhances the stability of USP4 in T cells [XREF_BIBR, XREF_BIBR], implying that USP39 might be deubiquitylating USP4."
28659380
USP39 affects SP1
| 1
USP39 leads to the deubiquitination of SP1. 1 / 1
| 1
reach
"USP39 promotes tumorigenesis by stabilizing and deubiquitinating SP1 protein in hepatocellular carcinoma."
34197957
USP39 affects CHEK2
| 1
USP39 deubiquitinates CHEK2. 1 / 1
| 1
reach
"Mechanistically, USP39 deubiquitinates and stabilizes CHK2, which in turn enhances CHK2 stability."
30771428
USP39 affects CCNB1
| 1
USP39 deubiquitinates CCNB1. 1 / 1
| 1
reach
"USP39 interacts with Cyclin B1 and stabilizes its expression by deubiquitinating Cyclin B1."
37302347
USP39 affects AURKB
1 |
USP39 deubiquitinates AURKB. 1 / 1
1 |
ubibrowser
"USP39 deubiquitinates aurora B kinase maintaining spindle assembly checkpoint integrity [103] while USP44 stabilizes Mad2/Cdc20 complex inhibiting premature activation of the APC/CCdh1?complex"
25121098