IndraLab

Statements

USP36 affects MYC
1 | 1 3
USP36 deubiquitinates MYC. 5 / 5
1 | 1 3
reach
"USP36 interacts with and deubiquitinates c-Myc in cells and in vitro, leading to the stabilization of c-Myc."
25775507
reach
"Recent evidence has revealed that c-Myc can be deubiquitylated and regulated by USP28, USP36 and USP37."
29263902
reach
"45 USP36 deubiquitinates and stabilizes c-Myc through interactions with FBW7gamma in the nucleolus."
29527331
trips
"The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc."
25775507
ubibrowser
"Review"
27919796
USP36 affects DOCK4
| 3
USP36 leads to the deubiquitination of DOCK4. 3 / 3
| 3
reach
"Further investigation into the mechanisms proved that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt/beta-catenin signaling pathway and induce EMT."
33968925
reach
"Further, we found that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt/β-catenin signaling pathway and induce EMT."
33968925
reach
"Additionally, USP36 directly bound to and mediated the de-ubiquitination of DOCK4, whereas DOCK4 knockdown effectively abolished EMT induced by USP36 overexpression through suppressing Wnt/β-catenin signaling in TECs (Zhu et al., 2021)."
35082683
USP36 affects NPM1
| 2
USP36 deubiquitinates NPM1. 2 / 2
| 2
reach
"We also tested whether a nucleolar deubiquitinase USP36, which deubiquitinates NPM XREF_BIBR, affects the MG132 caused NPM nucleolar retention in the UV treated cells."
23554979
reach
"It was shown that NPM1 is deubiquitinated by USP36 (ubiquitin specific peptidase 36) in the nucleolus stabilizing NPM1 [52], which is in turn required for USP36 accumulation [53]."
29157973
USP36 affects GEF
| 2
USP36 leads to the deubiquitination of GEF. 2 / 2
| 2
reach
"Further investigation into the mechanisms proved that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt/beta-catenin signaling pathway and induce EMT."
33968925
reach
"Further, we found that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt/β-catenin signaling pathway and induce EMT."
33968925
USP36 affects guanine
| 1
USP36 leads to the deubiquitination of guanine. 1 / 1
| 1
reach
"Further investigation into the mechanisms proved that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt and beta-catenin signaling pathway and induce EMT."
33968925
USP36 affects fibrillarin
| 1
USP36 deubiquitinates fibrillarin. 1 / 1
| 1
reach
"USP36 deubiquitylated the nucleolar proteins nucleophosmin and B23 and fibrillarin, and stabilized them by counteracting ubiquitylation mediated proteasomal degradation."
19208757
USP36 leads to the deubiquitination of dedicator of cytokinesis. 1 / 1
| 1
reach
"Further investigation into the mechanisms proved that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt and beta-catenin signaling pathway and induce EMT."
33968925
USP36 affects c-Myc [
| 1
USP36 deubiquitinates c-Myc [. 1 / 1
| 1
reach
"In a subset of human breast and lung cancers, USP36 interacts with and deubiquitinates c-Myc [XREF_BIBR]."
29142505
USP36 affects SOX9
| 1
USP36 deubiquitinates SOX9. 1 / 1
| 1
reach
"When these two long noncoding RNAs are lost, CHD7 is de-ubiquitinated by USP36 and then interacts with SOX9 to maintain a de-differentiated cellular state."
30200332
USP36 affects SOD2
1 |
USP36 deubiquitinates SOD2. 1 / 1
1 |
ubibrowser
"we identified a deubiquitinating enzyme USP36 that regulates the protein stability of SOD2"
21268071
USP36 affects SNAI1
| 1
USP36 leads to the deubiquitination of SNAI1. 1 / 1
| 1
reach
"Subsequent sub-screening identified 23 DUBs that interact with SNAI1, out of which USP29, USP36, and USP37 upregulate and reduce polyubiquitination of the SNAI1 protein."
| PMC
USP36 affects PPME1
1 |
USP36 deubiquitinates PPME1. 1 / 1
1 |
ubibrowser
"we demonstrate that USP36 regulates PME-1 through its deubiquitinating enzyme activity. USP36 increases PME-1 stability, and depletion of USP36 decreases the PME-1 expression level."
29577269
USP36 affects POLR1A
1 |
USP36 deubiquitinates POLR1A. 1 / 1
1 |
ubibrowser
"?In particular, we discovered that the largest subunit of RNA polymerase I (RNAPI) is stabilized via Ubp10-mediated deubiquitination.|USP36, the human ortholog of Ubp10, complements the ubp10螖 allele for RNAPI stability, pre-rRNA processing, and cell growth in yeast, suggesting that deubiquitination of RNAPI may be conserved in eukaryotes."
22902402
USP36 affects NTRK1
| 1
Modified USP36 leads to the deubiquitination of NTRK1. 1 / 1
| 1
reach
"Instead, USP36 interfered with the binding of Nedd4-2 to TrkA, and hence USP36 expression impaired the Nedd4-2-mediated ubiquitination of TrkA [XREF_BIBR]."
28335430
USP36 affects MYCN
| 1
USP36 deubiquitinates MYCN. 1 / 1
| 1
reach
"These results indicate that USP36 interacts with and deubiquitinates MYCN, thereby promoting the stability of MYCN."
34056606
USP36 affects Imd
| 1
USP36 deubiquitinates Imd. 1 / 1
| 1
reach
"USP36 deubiquitinates Imd for its degradation and, thus, represses Imd signaling."
25858029
USP36 affects Histone_H2B
| 1
USP36 deubiquitinates Histone_H2B. 1 / 1
| 1
reach
"Scrawny is an ubiquitin specific protease, homologue of human USP36 and yeast UBP10, which deubiquitylates histone H2B and functions in gene silencing."
25294944
USP36 affects H2Bub1
| 1
USP36 deubiquitinates H2Bub1. 1 / 1
| 1
reach
"We show that USP36 interacts with H2B and deubiquitinates H2Bub1 in cells and invitro."
29274341
USP36 affects H2BC21
1 |
USP36 deubiquitinates H2BC21. 1 / 1
1 |
ubibrowser
No evidence text available
USP36 affects DHX33
1 |
USP36 deubiquitinates DHX33. 1 / 1
1 |
ubibrowser
"Collectively, these results support that Usp36 is essential for cell and organism viability because of its role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, by regulating DHX33 stability."
29273634
USP36 affects CHD7
| 1
USP36 deubiquitinates CHD7. 1 / 1
| 1
reach
"When these two long noncoding RNAs are lost, CHD7 is de-ubiquitinated by USP36 and then interacts with SOX9 to maintain a de-differentiated cellular state."
30200332
USP36 affects CFTR
| 1
USP36 deubiquitinates CFTR. 1 / 1
| 1
reach
"USP36 associated with immunoprecipitated p.Phe508del-CFTR (XREF_FIG) and deubiquitinated CFTR in Rab5 + and more so Rab9 + endosomes in Talpha1 treated cells (XREF_FIG)."
28394330
USP36 affects C-MYC
| 1
USP36 deubiquitinates C-MYC. 1 / 1
| 1
trips
"USP36 interacts with and deubiquitinates c-Myc in cells and in vitro, leading to the stabilization of c-Myc."
25775507
USP36 affects B23
| 1
USP36 deubiquitinates B23. 1 / 1
| 1
reach
"USP36 deubiquitylated the nucleolar proteins nucleophosmin and B23 and fibrillarin, and stabilized them by counteracting ubiquitylation mediated proteasomal degradation."
19208757