IndraLab

Statements

USP30 affects TOMM20
1 | 2
USP30 leads to the deubiquitination of TOMM20. 2 / 2
1 | 1
reach
"USP30 depletion promotes ubiquitylation of TOM20 and depolarization‐induced cell death [19]."
34381024
ubibrowser
"Review"
28279784
Modified USP30 leads to the deubiquitination of TOMM20. 1 / 1
| 1
reach
"As expected, expression of WT USP30, but not a catalytically inactive mutant (C77A), reversed TOMM20 ubiquitylation, but did not affect MFN2 or CISD1 ubiquitylation (XREF_FIG, XREF_SUPPLEMENTARY)."
25284222
USP30 affects OMM proteins
| 3
USP30 deubiquitinates OMM proteins. 3 / 3
| 3
reach
"Previous results from cell culture experiments and flies suggest that USP30 can deubiquitylate OMM proteins and antagonize Parkin’s activity ."
33890401
reach
"Recent advances have demonstrated that USP30 can counteract Parkin-dependent mitophagy by deubiquitylating OMM proteins, including TOMM20 ."
33890401
reach
"At present, the negative regulatory mechanisms against Parkin-mediated ubiquitination have been reported, with the discovery of several deubiquitinases including USP8, USP15 and USP30 that are able to cause the deubiquitination of Parkin and/or OMM proteins."
29934616
USP30 affects PolgammaA
| 2
USP30 deubiquitinates PolgammaA. 2 / 2
| 2
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"In both the conditions, USP30 could deubiquitylate PolgammaA (XREF_SUPPLEMENTARY)."
33657094
reach
"For example, while we observe that USP30 deubiquitylates PolgammaA in vitro, its expression in asynchronously growing cells does not rescue MITOL dependent decrease in the level PolgammaA nor alter the extent of PolgammaA ubiquitylation."
33657094
USP30 affects PRKN
| 2
USP30 deubiquitinates PRKN. 2 / 2
| 2
reach
"Reciprocally, the dequbiquitination enzymes USP30 and USP35 have been shown to antagonize the mitophagy process by deubiquitinating Parkin [138,139]."
30544615
reach
"At present, the negative regulatory mechanisms against Parkin-mediated ubiquitination have been reported, with the discovery of several deubiquitinases including USP8, USP15 and USP30 that are able to cause the deubiquitination of Parkin and/or OMM proteins."
29934616
USP30 affects VDAC1
1 |
USP30 deubiquitinates VDAC1. 1 / 1
1 |
USP30 affects TOMM70
1 |
USP30 deubiquitinates TOMM70. 1 / 1
1 |
ubibrowser
"Similar findings were reported for another DUB: USP30. USP30 overexpression impaired PARKIN-mediated mitophagy by deubiquitinating mitochondrial substrates that include TOM20, TOM70, and the VDACs"
25995186
USP30 affects TOM complex components
| 1
USP30 deubiquitinates TOM complex components. 1 / 1
| 1
reach
"USP30 deubiquitylation of TOM complex components dampens the trigger for the Parkin dependent amplification of mitochondrial ubiquitylation leading to mitophagy."
32636217
USP30 affects RHOT1
1 |
USP30 deubiquitinates RHOT1. 1 / 1
1 |
ubibrowser
No evidence text available
USP30 affects NLRP3
| 1
USP30 deubiquitinates NLRP3. 1 / 1
| 1
reach
"Mechanistically, we demonstrate that USP30 activates the NLRP3 inflammasome by deubiquitinating NLRP3."
34883112
USP30 affects MFN2
1 |
USP30 deubiquitinates MFN2. 1 / 1
1 |
ubibrowser
"USP30, a mitochondrial deubiquitinase, promotes mitochondrial fusion by mediating the deubiquitination of ubiquitylated forms of mitofusins, such as Mfn1 and Mfn2."
29178074
USP30 affects MFN1
1 |
USP30 deubiquitinates MFN1. 1 / 1
1 |
ubibrowser
"USP30, a mitochondrial deubiquitinase, promotes mitochondrial fusion by mediating the deubiquitination of ubiquitylated forms of mitofusins, such as Mfn1 and Mfn2."
29178074
USP30 affects MARCHF5
| 1
USP30 deubiquitinates MARCHF5. 1 / 1
| 1
reach
"We wanted to test whether USP30 could deubiquitylate MITOL mediated ubiquitylation on PolgammaA."
33657094
USP30 affects FAM126A
| 1
USP30 deubiquitinates FAM126A. 1 / 1
| 1
reach
"In addition, IKKβ-phosphorylated ACLY binds to IKKβ-phosphorylated and stabilized ubiquitin-specific protease–30 (USP30), which deubiquitinates and stabilizes ACLY in HCC cells (Gu et al., 2020)."
33601415
USP30 affects DNM1L
| 1
USP30 deubiquitinates DNM1L. 1 / 1
| 1
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"Mechanistically, GNPAT recruited the enzyme USP30, which deubiquitylated and stabilized dynamin related protein 1 (DRP1), thereby facilitating regulation of mitochondrial morphology, lipid metabolism, and hepatocarcinogenesis."
30143522
USP30 affects DENR
| 1
USP30 deubiquitinates DENR. 1 / 1
| 1
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"USP30 can deubiquitinate and stabilize mitochondrial division protein DRP1, promote mitochondrial morphology, and thus regulate lipid metabolism and the occurrence of liver cancer [21]."
34694569
USP30 affects BAX
| 1
USP30 leads to the deubiquitination of BAX. 1 / 1
| 1
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"A plausible explanation is that USP30 is the DUB of Bax, and USP30 inhibition-mediated Bax ubiquitination induces the translocation of pro-apoptotic Bax on the mitochondria."
34381024
USP30 affects ACLY
| 1
USP30 deubiquitinates ACLY. 1 / 1
| 1
reach
"In addition, IKKβ-phosphorylated ACLY binds to IKKβ-phosphorylated and stabilized ubiquitin-specific protease–30 (USP30), which deubiquitinates and stabilizes ACLY in HCC cells (Gu et al., 2020)."
33601415