IndraLab

Statements

USP30 deubiquitinates TOMM20. 3 / 4
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"USP30 deubiquitinates TOM20, thereby limiting PINK1/PARKIN-mediated mitochondrial autophagy and restricting BAX/BAK-induced apoptosis, and is considered a potential target in Parkinson’s disease [17, 18]."
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"USP30 can also directly deubiquitinate MFN2 and TOMM20 to delay the recruitment of Parkin to mitochondria and subsequent mitophagy."
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"USP30 depletion promotes ubiquitylation of TOM20 and depolarization‐induced cell death [19]."
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