IndraLab

Statements

USP30 deubiquitinates PRKN. 6 / 6
| 6
reach
"Thus, USP15 and USP30 both deubiquitinate substrates of PARKIN and oppose PARKIN function in mitophagy."
25995186
reach
"Moreover, both USP15 and USP30 function indirectly, deubiquitinating substrates of PARKIN."
25995186
reach
"At present, the negative regulatory mechanisms against Parkin-mediated ubiquitination have been reported, with the discovery of several deubiquitinases including USP8, USP15 and USP30 that are able to cause the deubiquitination of Parkin and/or OMM proteins."
29934616
reach
"Parkin ubiquitination is antagonized by several deubiquitinating enzymes, including USP30 and USP35, both localized to the outer mitochondrial membrane (Wang et al., 2015)."
30700497
reach
"USP15 and USP30 inhibit mitophagy by deubiquitylating Parkin targets on the mitochondrial surface [ 13 • ,48 •• ,49 •• ] ( Table 1 )."
26343990
reach
"Studies have revealed that the deubiquitinating enzyme ubiquitin specific peptidase 30 (USP30) negatively regulates mitophagy by mediating PRKN deubiquitination (Gersch et al., 2017)."
37538379