IndraLab

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USP30 deubiquitinates MFN1. 3 / 3
1 | 2

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"Additionally, USP30 promotes mitochondrial fusion by deubiquitinating Mfn1 and Mfn2."

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"Specifically, studies performed in HeLa cells overexpressing c-Myc-tagged Ubiquitination Proteasome System (USP) demonstrated that S3 targets a mitochondria-localized deubiquitinase USP30, which mediates deubiquitination of MFN1 and MFN2 and regulates mitochondrial morphology."

"<span class="match term0">USP30</span>, a mitochondrial deubiquitinase, promotes mitochondrial fusion by mediating the deubiquitination of ubiquitylated forms of mitofusins, such as <span class="match term1">Mfn1</span> and Mfn2."