IndraLab

Statements


USP29 affects TP53
1 | 2
USP29 deubiquitinates TP53. 3 / 3
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"USP29 can also deubiquitinate p53 in response to oxidative stress."

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"USP29 is transcriptionally activated following oxidative stress and then mediates p53 deubiquitination."
USP29 affects CGAS
| 3
USP29 deubiquitinates CGAS-K464R. 2 / 2
| 2

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"In support of this notion, we found that USP29 deubiquitinated cGAS (K464R) but did not affect the ubiquitination of cGAS (K271R)."

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"In this context, we noted that USP29 inhibited ubiquitination of cGAS (K464R) but not cGAS (K271R) after HSV-1 infection, and that knockout of USP29 potentiated ubiquitination of cGAS (K464R) but not cGAS (K271R) before or after HSV-1 infection."
USP29 deubiquitinates CGAS. 1 / 1
| 1

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"USP29 deubiquitinates cGAS in the presence or absence of HSV-1 infection."
USP29 affects KMT5A
| 2
USP29 deubiquitinates KMT5A. 2 / 2
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"Wildtype USP29 can deubiquitinate SETD8 in vivo, indicating that USP29 directly regulates SETD8 protein levels."

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"USP29 Deubiquitinates SETD8 and Regulates DNA Damage-Induced H4K20 Monomethylation and 53BP1 Focus Formation."
USP29 affects TWIST1
| 1
USP29 leads to the deubiquitination of TWIST1. 1 / 1
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"The deubiquitination of TWIST1 catalyzed by USP29 is required for its stabilization and subsequent EMT and CSC functions in TNBC, thereby conferring chemotherapeutic resistance and metastasis."
USP29 affects HIF1A
| 1
USP29 deubiquitinates HIF1A. 1 / 1
| 1

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"USP29 interacts with and deubiquitylates HIF1alpha."
USP29 affects HIF1
| 1
USP29 leads to the deubiquitination of HIF1. 1 / 1
| 1

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"The removal of ubiquitin on HIF1α seemed to be directly catalyzed by USP29, since a catalytically inactive form of USP29 (CA) failed to reduce ubiquitination of HIF1α (Fig. 3d) and, as a consequence, the CA form of USP29 was unable to stabilize HIF1α."
USP29 affects H2AC20
1 |
USP29 deubiquitinates H2AC20. 1 / 1
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"Both USP44 and USP29 promoted efficient deubiquitylation of histone H2A"
USP29 affects CLSPN
1 |
USP29 deubiquitinates CLSPN. 1 / 1
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"USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination"
USP29 affects CDC25A
| 1
USP29 leads to the deubiquitination of CDC25A. 1 / 1
| 1

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"The presence of USP29 effectively blocked polyubiquitination of Cdc25A and extended its half-life."