IndraLab

Statements

USP29 deubiquitinates KMT5A. 5 / 5
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"USP29 Deubiquitinates SETD8 and Regulates DNA Damage-Induced H4K20 Monomethylation and 53BP1 Focus Formation."
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"Wildtype USP29 can deubiquitinate SETD8 in vivo, indicating that USP29 directly regulates SETD8 protein levels."
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"Furthermore, USP29 deubiquitinates SETD8 in vivo and controls the DNA damage-induced monomethylation of H4K20 and focus formation of 53BP1."
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"USP29 Deubiquitinates SETD8 In Vivo."
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"Indeed, overexpression of wildtype USP29 diminished polyubiquitination of SETD8 in vivo, whereas the polyubiquitinated SETD8 was less affected by a co-expression of a catalytic inactive version of the ubiquitin hydrolase.We next demonstrated that the depletion of USP29 inhibited the accumulation of 53BP1 into foci after treating the cells with IR."
36010569