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USP29 deubiquitinates TWIST1. 5 / 5
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"The deubiquitination of TWIST1 catalyzed by USP29 is required for its stabilization and subsequent EMT and CSC functions in TNBC, thereby conferring chemotherapeutic resistance and metastasis."
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"The result of immunofluorescence staining also showed the co‐localization of USP29 with TWIST1 in the nucleus of TNBC cells (Figure 1G).2.2 USP29 Deubiquitinates and Stabilizes TWIST1."
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"These data reveal USP29‐mediated deubiquitination of TWIST1 as a critical mechanism controlling its stability."
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"Next, the specific ubiquitin linkage of TWIST1 deubiquitinated by USP29 was examined."
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"Guan et al. showed that in triple-negative breast cancer, CDK1 leads to the de-ubiquitination of TWIST1 by USP29, which conferred resistance to both cisplatin and paclitaxel [103]."
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