IndraLab

Statements

USP29 deubiquitinates CGAS. 3 / 3
1 | 2
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"Mechanistically, <span class="match term0">USP29</span> constitutively interacts with <span class="match term1">cGAS</span>, deconjugates K48-linked polyubiquitin chains from <span class="match term1">cGAS</span> and stabilizes <span class="match term1">cGAS</span> in uninfected cells or after HSV-1 infection"
32457395
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"USP27X and USP29 have a similar mechanism for the deubiquitination of cGAS, both preventing the degradation of cGAS via the proteasomal pathway by removing the K48-linked ubiquitin chain of cGAS and maintaining cGAS protein levels."
36579404
reach
"USP29 deubiquitinates cGAS in the presence or absence of HSV-1 infection."
32457395