IndraLab

Statements

TNFAIP3 affects RIPK1
3 1 | 4
TNFAIP3 deubiquitinates RIPK1. 5 / 5
1 | 4
reach
"TNFAIP3 causes inhibition of the canonical NF-kappaB pathway by deubiquitinating RIP1, thus abolishing the recruitment of the TAK1, TAK1 binding protein 2, and NEMO complex."
23935380
reach
"TNFAIP3 (A20) leads to the ubiquitination of TRAF6 and the deubiquitination of RIP to inhibit the activation of the NF-kappaB signaling pathway that is mediated by NOD1 and NOD2."
33013823
ubibrowser
"The targets of A20-mediated deubiquitination are K63-linked ubiquitinated TRAF6 and RIP1"
25121098
reach
"However, LMP1 is also known to upregulate TNFAIP3/A20 (TNFa-induced protein 3), which could deubiquitinate RIPK1 (98, 99) ."
34372694
reach
"However, LMP1 is also known to upregulate TNFAIP3/A20 (TNF-α-induced protein 3), which could deubiquitinate RIPK1 (98, 99)."
34372694
TNFAIP3 deubiquitinates RIPK1 on K377. 3 / 3
3 |
biopax:pid
No evidence text available
15258597
biopax:pid
No evidence text available
8692885
biopax:reactome
No evidence text available
TNFAIP3 affects OCLN
1 | 3
TNFAIP3 deubiquitinates OCLN. 4 / 4
1 | 3
reach
"To determine whether TNFAIP3 can deubiquitinate occludin, we incubated recombinant N-terminal TNFAIP3 with ubiquitinated occludin in vitro."
22031828
reach
"Thus TNFAIP3 associates with occludin and can deubiquitinate occludin."
22031828
ubibrowser
"We also found that TNFAIP3 deubiquitinates polyubiquitinated occludin."
22031828
reach
"We found that TNFAIP3 was able to decrease the total ubiquitination of occludin (XREF_FIG)."
22031828
TNFAIP3 affects MAP3K5
1 | 2
TNFAIP3 deubiquitinates MAP3K5. 3 / 3
1 | 2
reach
"In screening for proteins that interact with ASK1 in the context of NASH, we identified the deubiquitinase tumor necrosis factor alpha induced protein 3 (TNFAIP3) as a key endogenous suppressor of ASK1 activation, and we found that TNFAIP3 directly interacts with and deubiquitinates ASK1 in hepatocytes."
29227477
reach
"The deubiquitinating enzyme tumor necrosis factor-alpha-induced protein 3 (TNFAIP3) directly interacts with and deubiquitinates ASK1 in hepatocytes and ameliorates metabolic stress-induced hepatic inflammation and fibrosis (144)."
34746195
ubibrowser
"we identified the deubiquitinase tumor necrosis factor alpha-induced protein 3 (TNFAIP3) as a key endogenous suppressor of ASK1 activation, and we found that TNFAIP3 directly interacts with and deubiquitinates ASK1 in hepatocytes."
29227477
TNFAIP3 affects TRAF6
1 1 |
TNFAIP3 deubiquitinates TRAF6. 2 / 2
1 1 |
signor
"A20 is a deubiquitinating enzyme (dub) for lys63-linked polyubiquitinated signaling mediators such as traf6"
18164316
ubibrowser
"The targets of A20-mediated deubiquitination are K63-linked ubiquitinated TRAF6 and RIP1"
25121098
TNFAIP3 affects RIPK2
1 1 |
TNFAIP3 deubiquitinates RIPK2. 1 / 1
1 |
ubibrowser
"Activation of RIPK2 depends on its K63 ubiquitination by E3 ligases, whereas the deubiquitinating enzyme A20 counter regulates RIPK2 activity by cleaving K63-polyubiquitin chains from RIPK2."
26834734
TNFAIP3 deubiquitinates RIPK2 on K209. 1 / 1
1 |
biopax:reactome
No evidence text available
TNFAIP3 affects IKBKG
1 | 1
TNFAIP3 deubiquitinates IKBKG. 2 / 2
1 | 1
reach
"The overexpression of GIT2 enhanced the deubiquitination activity of TNFAIP3 toward IKBKG, and siRNA targeted at GIT2 abrogated the TNFAIP3 dependent deubiquitination of IKBKG and impaired the ability of TNFAIP3 to inhibit NF-kappaB activation (XREF_FIG)."
21988832
ubibrowser
"Review"
27775833
TNFAIP3 affects TRAF2
1 |
TNFAIP3 deubiquitinates TRAF2. 1 / 1
1 |
ubibrowser
"A tight control in TNF-a led NF-kB activation is exerted byA20 as it targets both RIP1 and TRAF2 through different mechanisms."
24673262
TNFAIP3 affects TP53
1 |
TNFAIP3 deubiquitinates TP53. 1 / 1
1 |
TNFAIP3 affects Proteasome
| 1
TNFAIP3 leads to the deubiquitination of Proteasome. 1 / 1
| 1
reach
"TNFAIP3 and TAX1BP1 inhibit the inflammatory signaling pathway by interacting with Ubc13 and UbcH5c and triggering their ubiquitination and proteasome dependent degradation [XREF_BIBR]."
25883971
TNFAIP3 affects NFKB1
1 |
TNFAIP3 deubiquitinates NFKB1. 1 / 1
1 |
TNFAIP3 affects IRF7
1 |
TNFAIP3 deubiquitinates IRF7. 1 / 1
1 |
ubibrowser
"Thus, A20 negatively regulates LMP1-stimulated IRF7 ubiquitination and activity in EBV latency, and its DUB activity is indispensable for this function."
20392859
TNFAIP3 affects CASP8
1 |
TNFAIP3 deubiquitinates CASP8. 1 / 1
1 |
ubibrowser
"Apo2L induces both K48 and K63-linked polyubiquitination of caspase 8."
25121098
TNFAIP3 affects CALCOCO2
1 |
TNFAIP3 deubiquitinates CALCOCO2. 1 / 1
1 |
ubibrowser
"NDP52 itself has to be activated by the E3 ligase TRAF6 via the attachment of Lys63-linked polyubiquitin chains. A20 counteracts the function of NDP52 in order to prevent an overactivation.?"
26445063
TNFAIP3 affects BECN1
1 |
TNFAIP3 deubiquitinates BECN1. 1 / 1
1 |
ubibrowser
"However, this TRAF6-dependent polyubiquitination of Beclin 1 is antagonized by the deubiquitinase A20"
26445063