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TNFAIP3 deubiquitinates MAP3K5. 4 / 4
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"we identified the deubiquitinase tumor necrosis factor alpha-induced protein 3 (<span class="match term0">TNFAIP3</span>) as a key endogenous suppressor of <span class="match term1">ASK1</span> activation, and we found that <span class="match term0">TNFAIP3</span> directly interacts with and deubiquitinates <span class="match term1">ASK1</span> in hepatocytes."
29227477
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"In screening for proteins that interact with ASK1 in the context of NASH, we identified the deubiquitinase tumor necrosis factor alpha induced protein 3 (TNFAIP3) as a key endogenous suppressor of ASK1 activation, and we found that TNFAIP3 directly interacts with and deubiquitinates ASK1 in hepatocytes."
29227477
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"The deubiquitinating enzyme tumor necrosis factor-alpha-induced protein 3 (TNFAIP3) directly interacts with and deubiquitinates ASK1 in hepatocytes and ameliorates metabolic stress-induced hepatic inflammation and fibrosis (144)."
34746195
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"Moreover, TNF-alpha-induced protein 3 (TNFAIP3) promotes the deubiquitination of ASK1 in hepatocytes with an anti-inflammatory effect [250]."
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