IndraLab

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TNFAIP3 deubiquitinates RIPK1. 5 / 5
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"TNFAIP3 causes inhibition of the canonical NF-kappaB pathway by deubiquitinating RIP1, thus abolishing the recruitment of the TAK1, TAK1 binding protein 2, and NEMO complex."
23935380
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"TNFAIP3 (A20) leads to the ubiquitination of TRAF6 and the deubiquitination of RIP to inhibit the activation of the NF-kappaB signaling pathway that is mediated by NOD1 and NOD2."
33013823
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"The targets of A20-mediated deubiquitination are K63-linked ubiquitinated TRAF6 and RIP1"
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"However, LMP1 is also known to upregulate TNFAIP3/A20 (TNFa-induced protein 3), which could deubiquitinate RIPK1 (98, 99) ."
34372694
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"However, LMP1 is also known to upregulate TNFAIP3/A20 (TNF-α-induced protein 3), which could deubiquitinate RIPK1 (98, 99)."
34372694