IndraLab

Statements

TNFAIP3 deubiquitinates RIPK1. 4 / 5
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"However, LMP1 is also known to upregulate TNFAIP3/A20 (TNF-α-induced protein 3), which could deubiquitinate RIPK1 (98, 99)."
34372694
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"In GC, the C2H2-type TNFAIP3 can interact with RIP1 and DR4, and a low expression of TNFAIP3 can prevent the polyubiquitination of RIP1, promote the cleavage of caspase-8 and then inhibit DISC formation, eventually suppressing apoptosis [81]."
37174714
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"For example, TNFAIP3, CYLD, USP3, USP4, USP15, USP25, and OTUD5 deubiquitinate key components of the IFN production pathway, including RIG-I, TRAF2, TRAF3, TRAF6, RIP1, and TRIF (reviewed in [93,94])."
38716888
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"TNFAIP3 causes inhibition of the canonical NF-kappaB pathway by deubiquitinating RIP1, thus abolishing the recruitment of the TAK1, TAK1 binding protein 2, and NEMO complex."
23935380