IndraLab

Statements

OTUD4 affects XPC
1 | 2
OTUD4 deubiquitinates XPC. 3 / 3
1 | 2
reach
"We speculate that deubiquitination of XPC by OTUD4 could be responsible for the removal of XPC from damage sites, possibly leading to XPC recycling."
24366067
reach
"It is not known whether OTUD4 works independently or cooperatively with USP7 to deubiquitinate XPC."
27696486
ubibrowser
"Importantly, we validated the XPC-OTUD4 interaction by co-IP and provided evidence that OTUD4 knockdown in human cells indeed affects the levels of ubiquitinated XPC, supporting a hypothesis that the OTUD4 deubiquitinase is involved in XPC recycling by cleaving the ubiquitin moiety."
24366067
OTUD4 affects MAVS
1 | 2
OTUD4 deubiquitinates MAVS. 3 / 3
1 | 2
reach
"That study showed that OTUD4 deubiquitinates and stabilizes MAVS, thereby activating downstream signaling in the RIG-I like receptor RNA sensing pathway."
35516420
reach
"However, OTUD4 positively regulates IFN signaling and enhances host antiviral activities by deubiquitinating K48-Ub on MAVS (66)."
34707613
ubibrowser
"Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS"
30410068
OTUD4 affects GSDME
| 1
OTUD4 deubiquitinates GSDME. 1 / 1
| 1
reach
"GSDME-dependent pyroptosis is a critical determinant of radiosensitivity in NPC, and is modulated by OTUD4 via deubiquitinating and stabilizing GSDME."
36411454
OTUD4 affects ALKBH3
| 1
OTUD4 deubiquitinates ALKBH3. 1 / 1
| 1
reach
"Besides USP11, OTUD4 is another USP7 partner that deubiquitinates DNA demethylases ALKBH2 and ALKBH3 [118]."
33991872
OTUD4 affects ALKBH2
| 1
OTUD4 deubiquitinates ALKBH2. 1 / 1
| 1
reach
"Besides USP11, OTUD4 is another USP7 partner that deubiquitinates DNA demethylases ALKBH2 and ALKBH3 [118]."
33991872