IndraLab

Statements

OTUD4 deubiquitinates GSDME. 7 / 7
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"GSDME-dependent pyroptosis is a critical determinant of radiosensitivity in NPC, and is modulated by OTUD4 via deubiquitinating and stabilizing GSDME."
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"OTUD4 deubiquitinates and stabilizes GSDME."
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"In agreement with these findings, the overexpression of OTUD4 attenuated GSDME polyubiquitination (Fig. 5K)."
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"These results indicate that OTUD4 promotes the deubiquitination and stability of GSDME in NPC."
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"OTUD4 deubiquitinated and stabilized GSDME, thereby increasing GSDME-dependent pyroptosis and boosting radiosensitivity in NPC cells."
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"Additionally, OTUD4 deubiquitinates and stabilizes GSDME, resulting in increased levels of GSDME protein and radiation-induced pyroptosis, ultimately enhancing the radiosensitivity of NPC."
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"Furthermore, activated GSDME-induced pyroptosis enhances the radiosensitivity of colorectal cancer (89), and Di et al (90) revealed that the effect of GSDME on radiosensitivity is associated with GSDME deubiquitylation mediated by OTU deubiquitinase 4 in nasopharyngeal carcinoma."
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