IndraLab

Statements

OTUD4 deubiquitinates XPC. 3 / 3
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"We speculate that deubiquitination of XPC by OTUD4 could be responsible for the removal of XPC from damage sites, possibly leading to XPC recycling."
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"It is not known whether OTUD4 works independently or cooperatively with USP7 to deubiquitinate XPC."
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"Importantly, we validated the XPC-OTUD4 interaction by co-IP and provided evidence that OTUD4 knockdown in human cells indeed affects the levels of ubiquitinated XPC, supporting a hypothesis that the OTUD4 deubiquitinase is involved in XPC recycling by cleaving the ubiquitin moiety."
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