IndraLab

Statements

OTUD4 deubiquitinates XPC. 3 / 3
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"We speculate that deubiquitination of XPC by OTUD4 could be responsible for the removal of XPC from damage sites, possibly leading to XPC recycling."
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"It is not known whether OTUD4 works independently or cooperatively with USP7 to deubiquitinate XPC."
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"Importantly, we validated the <span class="match term1">XPC</span>-<span class="match term0">OTUD4</span> interaction by co-IP and provided evidence that <span class="match term0">OTUD4</span> knockdown in human cells indeed affects the levels of ubiquitinated <span class="match term1">XPC</span>, supporting a hypothesis that the <span class="match term0">OTUD4</span> deubiquitinase is involved in <span class="match term1">XPC</span> recycling by cleaving the ubiquitin moiety."
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