IndraLab

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OTUD4 deubiquitinates MAVS. 3 / 3
1 | 2

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"That study showed that OTUD4 deubiquitinates and stabilizes MAVS, thereby activating downstream signaling in the RIG-I like receptor RNA sensing pathway."

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"However, OTUD4 positively regulates IFN signaling and enhances host antiviral activities by deubiquitinating K48-Ub on MAVS (66)."

"Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS"