IndraLab

Statements

OTUB2 affects TRAF3
1 | 7
OTUB2 deubiquitinates TRAF3. 8 / 8
1 | 7
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"OTUB1 and OTUB2 interact with and deubiquitinate TRAF3 and TRAF6, which are required for virus triggered IRF3 and NF-kappaB activation [XREF_BIBR]."
23151130
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"Furthermore, we found that OTUB1 and OTUB2 mediated virus triggered deubiquitination of TRAF3 and -6."
19996094
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"Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6"
19996094
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"OTUB1 and its paralog OTUB2, deubiquitinate TRAF3 and TRAF6 to inhibit virus triggered signaling pathways that ultimately result in IRF3 and NF-kappaB activation [XREF_BIBR]."
23845989
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"Two close relatives of DUBA, OTUB1 and OTUB2, were shown to reduce TRAF3 ubiquitination coupled with decreased anti-viral signaling responses in Sendai virus infected HEK 293T cells."
22017431
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"It was also shown that two OTUB deubiquitinating enzyme family members, OTUB1 and OTUB2, can deubiquitinate TRAF3 and TRAF6, leading to the inhibition of virus induced IFN-beta expression and cellular antiviral responses."
28717359
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"It was also shown that two OTUB deubiquitinating enzyme family members, OTUB1 and OTUB2, can deubiquitinate TRAF3 and TRAF6, leading to the inhibition of virus-induced IFN-β expression and cellular antiviral responses (53)."
28717359
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"OTUB1 and OTUB2 regulate virus-triggered IFN inflammation by deubiquitinating TRAF3 and TRAF6 [75]."
32650621
OTUB2 affects L3MBTL1
1 | 6
OTUB2 deubiquitinates L3MBTL1. 7 / 7
1 | 6
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"In addition, DSB induced L3MBTL1 ubiquitination (Acs et al., 2011) was also antagonized by OTUB2 in a DUB activity dependent manner."
24560272
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"These data suggest that the interaction between OTUB2 and L3MBTL1 is constitutive rather than DNA damage dependent.Next, we investigated whether OTUB2 could deubiquitinate L3MBTL1 in vivo."
24560272
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"However, OTUB2 deubiquitinates L3MBTL1 and suppresses the RNF8 mediated ubiquitination of L3MBTL1, which leads to less recruitment of RAP80 and 53BP1 to DSBs and therefore increases HR."
30831436
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"Mechanistically, OTUB2 suppresses RNF8-mediated L3MBTL1 ubiquitination and Lys 63-linked ubiquitin chain formation in a deubiquitinating activity-dependent manner."
24560272
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"Finally, we investigated whether OTUB2 could deubiquitinate L3MBTL1 in vitro."
24560272
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"Because ubiquitination of L3MBTL1 is a prerequisite for L3MBTL1 removal from damaged chromatin (Acs et al., 2011), we conclude that OTUB2 deubiquitinates L3MBTL1 and suppresses the accelerated removal[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24560272
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"Thus, OTUB2 deubiquitinates L3MBTL1 in vivo and in vitro."
24560272
OTUB2 affects TRAF6
1 | 5
OTUB2 deubiquitinates TRAF6. 6 / 6
1 | 5
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"It was also shown that two OTUB deubiquitinating enzyme family members, OTUB1 and OTUB2, can deubiquitinate TRAF3 and TRAF6, leading to the inhibition of virus induced IFN-beta expression and cellular antiviral responses."
28717359
reach
"It was also shown that two OTUB deubiquitinating enzyme family members, OTUB1 and OTUB2, can deubiquitinate TRAF3 and TRAF6, leading to the inhibition of virus-induced IFN-β expression and cellular antiviral responses (53)."
28717359
reach
"OTUB1 and OTUB2 regulate virus-triggered IFN inflammation by deubiquitinating TRAF3 and TRAF6 [75]."
32650621
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"OTUB1 and its paralog OTUB2, deubiquitinate TRAF3 and TRAF6 to inhibit virus triggered signaling pathways that ultimately result in IRF3 and NF-kappaB activation [XREF_BIBR]."
23845989
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"OTUB1 and OTUB2 interact with and deubiquitinate TRAF3 and TRAF6, which are required for virus triggered IRF3 and NF-kappaB activation [XREF_BIBR]."
23151130
ubibrowser
"Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6"
19996094
OTUB2 affects U2AF2
| 3
OTUB2 deubiquitinates U2AF2. 3 / 3
| 3
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"OTUB2 knockdown significantly enhanced the levels of U2AF2 ubiquitination and K48 linked polyubiquitin chains in H1299 cells, whereas OTUB2 overexpression significantly reduced the levels of U2AF2 ubiquitination and K48 linked polyubiquitin chains in XL-2 cells."
30662561
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"This finding led us to hypothesize that OTUB2 directly interacts with and deubiquitinates U2AF2."
30662561
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"Of note, U2AF2 deubiquitination by OTUB2 is important for U2AF2 stabilization."
30662561
OTUB2 affects eS7A
| 2
OTUB2 deubiquitinates eS7A on S40. 1 / 1
| 1
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"To examine whether Otu2 deubiquitinates eS7A directly in the 40S ribosome, recombinant His Otu2 was added to mono- and di ubiquitinated eS7A-3HA prepared from 40S ribosome fractions of otu2Deltaubp3DeltaeS7A-3HA cells."
33665564
OTUB2 deubiquitinates eS7A. 1 / 1
| 1
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"Otu2 and Ubp3 deubiquitinate eS7A in the distinct ribosome complexes."
33665564
OTUB2 affects RPS7
| 2
OTUB2 deubiquitinates RPS7. 2 / 2
| 2
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"Otu2 deubiquitinates eS7 in order to promote dissociation of the small ribosomal subunit from the mRNA upon completion of translation (129)."
34391779
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"In actively translating 80S ribosomes the ribosomal protein eS7 of the 40S subunit is monoubiquitinated by the E3 ligase Not4 and deubiquitinated by Otu2 upon ribosomal subunit recycling."
37169754
OTUB2 affects STAT1
| 1
OTUB2 leads to the deubiquitination of STAT1. 1 / 1
| 1
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"Mechanistically, OTUB2 promotes the deubiquitination and phosphorylation of signal transducer and activator of transcription 1 (STAT1) and subsequently regulates the transcription of calmodulin-like protein 3 (CALML3)."
36288705
OTUB2 affects Protease
| 1
OTUB2 deubiquitinates Protease. 1 / 1
| 1
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"A second shared gene of interest is OTU2 that encodes a putative otubain related deubiquitylating protease XREF_BIBR, XREF_BIBR."
24009520
OTUB2 affects OTUB2
| 1
OTUB2 leads to the deubiquitination of OTUB2. 1 / 1
| 1
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"Because the accumulation of RNF168 at DSBs requires the E3 ubiquitin ligase activity of RNF8 and the accumulation of 53BP1, RAP80, and BRCA1 requires recruitment of RNF168 to DSBs (Doil et al., 2009; [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24560272
OTUB2 affects Histone
| 1
OTUB2 leads to the deubiquitination of Histone. 1 / 1
| 1
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"However, OTUB2 does not suppress histone ubiquitination induced by RNF168 overexpression [XREF_BIBR]."
26983989
OTUB2 affects GLI2
| 1
OTUB2 leads to the deubiquitination of GLI2. 1 / 1
| 1
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"We also found that knockdown of OTUB2 reduced deubiquitination of Gli2 invivo."
30241937