IndraLab

Statements

OTUB2 deubiquitinates U2AF2. 3 / 3
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"OTUB2 knockdown significantly enhanced the levels of U2AF2 ubiquitination and K48 linked polyubiquitin chains in H1299 cells, whereas OTUB2 overexpression significantly reduced the levels of U2AF2 ubiquitination and K48 linked polyubiquitin chains in XL-2 cells."
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"This finding led us to hypothesize that OTUB2 directly interacts with and deubiquitinates U2AF2."
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"Of note, U2AF2 deubiquitination by OTUB2 is important for U2AF2 stabilization."
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