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OTUB2 deubiquitinates L3MBTL1. 7 / 7
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"In addition, DSB induced L3MBTL1 ubiquitination (Acs et al., 2011) was also antagonized by OTUB2 in a DUB activity dependent manner."
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"These data suggest that the interaction between OTUB2 and L3MBTL1 is constitutive rather than DNA damage dependent.Next, we investigated whether OTUB2 could deubiquitinate L3MBTL1 in vivo."
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"However, OTUB2 deubiquitinates L3MBTL1 and suppresses the RNF8 mediated ubiquitination of L3MBTL1, which leads to less recruitment of RAP80 and 53BP1 to DSBs and therefore increases HR."
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"Mechanistically, OTUB2 suppresses RNF8-mediated L3MBTL1 ubiquitination and Lys 63-linked ubiquitin chain formation in a deubiquitinating activity-dependent manner."
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"Finally, we investigated whether OTUB2 could deubiquitinate L3MBTL1 in vitro."
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"Because ubiquitination of L3MBTL1 is a prerequisite for L3MBTL1 removal from damaged chromatin (Acs et al., 2011), we conclude that OTUB2 deubiquitinates L3MBTL1 and suppresses the accelerated removal[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, OTUB2 deubiquitinates L3MBTL1 in vivo and in vitro."
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