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OTUB2 deubiquitinates TRAF6. 10 / 11
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"OTUB2 promotes proliferation and metastasis of triple-negative breast cancer by deubiquitinating TRAF6."
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"OTUB2 deubiquitinates TRAF6 and activates AKT."
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"Therefore, we examined the effects of OTUB2 on TRAF6 ubiquitination and found that OTUB2 overexpression reduced the polyubiquitination of TRAF6 (Fig. 5E)."
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"Based on these findings, we hypothesized that OTUB2 activates AKT by deubiquitinating TRAF6, thereby exerting a pro-oncogenic effect."
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"OTUB1 and OTUB2 interact with and deubiquitinate TRAF3 and TRAF6, which are required for virus triggered IRF3 and NF-kappaB activation [XREF_BIBR]."
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"The experimental results further confirmed that OTUB2 reduced the ubiquitination of TRAF6, thereby positively regulating its protein expression.Previous studies have shown that AKT signaling plays a pivotal role in various biological processes, including cell proliferation, invasion and apoptosis [44]."
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"It was also shown that two OTUB deubiquitinating enzyme family members, OTUB1 and OTUB2, can deubiquitinate TRAF3 and TRAF6, leading to the inhibition of virus induced IFN-beta expression and cellular antiviral responses."
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"OTUB1 and OTUB2 regulate virus-triggered IFN inflammation by deubiquitinating TRAF3 and TRAF6 [75]."
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"OTUB1 and OTUB2, which are members of the OTUB deubiquitinase superfamily, may deubiquitinate TRAF3 and TRAF6, stop SeV-induced NF-κB and IRF3 activation, and aid in viral replication [41] ."
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"OTUB1 and its paralog OTUB2, deubiquitinate TRAF3 and TRAF6 to inhibit virus triggered signaling pathways that ultimately result in IRF3 and NF-kappaB activation [XREF_BIBR]."
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