IndraLab

Statements

USP8 affects HGS
| 16 7
USP8 binds HGS.
| 8 7
USP8 binds HGS. 10 / 10
| 8 2
reach
"In somatic cells, USP8 interacts with the ESCRT-0 machinery [i.e., STAM (signal transducing adaptor molecule) and HGS (hepatocyte growth factor regulated tyrosine kinase substrate)] and its deubiquitinating activity regulates the endosomal sorting of ubiquitinated cargo between the recycling pathway and the lysosomal degradation pathway [XREF_BIBR]."
24709878
reach
"USP8 also interacts with the HRS and STAM complex."
18687060
reach
"Although the interaction between Mop, Cbl, Ubpy, and Hrs seems to play a role in the recycling of Fz, our present findings do not exclude a role for other unidentified proteins in this molecular cascade."
26224310
reach
"In an immunoprecipitation assay, we did not observe a strong physical interaction between Hrs and USP8 (not shown)."
24244405
reach
"Studies have shown that USP8 also interacts with and deubiquitinate Hrs, demonstrating multiple roles of USP8 in both cargo de-ubiquitination and ESCRT-0 stability during development, which is helpful to address the mechanisms of Hh signaling."
26973699
reach
"The human USP8 binds the Hrs binding partner (Hbp) and inhibits EGF receptor (EGFR) endocytosis, suggesting that USP8 may act to regulate endocytic traffic."
40061651
reach
"We provide evidence that Ubpy interacts with and deubiquitylates Hrs."
24574010
sparser
"In an immunoprecipitation assay, we did not observe a strong physical interaction between Hrs and USP8 (not shown)."
24244405
reach
"By binding to STAM and Hrs, USP8 stabilizes the ESCRT-0 complex, which is the crucial element directing ubiquitinated substrates toward MVB/lysosome-mediated degradation (Mizuno et al., 2006; Row et al., 2006)."
39576689
sparser
"A de-ubiquitinating enzyme UBPY interacts with the SH3 domain of Hrs binding protein via a novel binding motif Px(V/I)(D/N)RxxKP."
12176377
HGS binds USP8 and SMO. 2 / 2
| 2
sparser
"It is possible that Hrs competes with USP8 for binding Smo, as Hrs and USP8 directly interact with the same domain of Smo."
24244405
sparser
"However, we found that Hrs blocks Smo phosphorylation ( xref ), whereas USP8 does not xref , suggesting that Hrs and USP8 bind Smo in different conformation."
24244405
HERC4 binds USP8, UCHL5, and HGS. 1 / 1
| 1
sparser
"Herc4 interacts with USP8, UCHL5, and Hrs to regulate Smo ubiquitination."
30925584
STAM binds HGS and USP8. 1 / 1
| 1
sparser
"The Hrs-STAM endosomal sorting complex interacts with UBPY via the Src homology 3 domain of STAM [9] ."
17720156
USP8 binds STAMBP, STAM, and HGS. 1 / 1
| 1
sparser
"UBPY and AMSH interact with the Hrs-STAM complex and counteract ubiquitination of RTKs."
34198477
USP8 deubiquitinates HGS.
| 5
USP8 deubiquitinates HGS. 5 / 5
| 5
reach
"Studies have shown that USP8 also interacts with and deubiquitinate Hrs, demonstrating multiple roles of USP8 in both cargo de-ubiquitination and ESCRT-0 stability during development, which is helpful to address the mechanisms of Hh signaling."
26973699
reach
"Mop recruits Ubpy to promote the deubiquitination of Hrs."
26224310
reach
"Previous studies showed that Hrs is deubiquitinated by Ubpy."
26224310
reach
"USP8 also deubiquitinates and stabilizes HRS and STAM1/2, components of the ESCRT-0 complex, which initially recognizes ubiquitinated plasma membrane proteins and primes their lysosomal sorting on endosomes (Row et al., 2006)."
38180476
reach
"We provide evidence that Ubpy interacts with and deubiquitylates Hrs."
24574010
USP8 decreases the amount of HGS.
| 2
USP8 decreases the amount of HGS. 1 / 1
| 1
reach
"UBPy deficient cells exhibit aberrantly enlarged early endosomes colocalizing with enhanced ubiquitination and have reduced levels of HRS and STAM2."
17452457
Modified USP8 decreases the amount of HGS. 1 / 1
| 1
reach
"Similarly, the overexpression of Ubpy can also rescue the loss of Hrs in mop knockdown by removing the ubiquitin moiety from Hrs."
26224310
USP8 ubiquitinates HGS.
| 1
USP8 leads to the ubiquitination of HGS. 1 / 1
| 1
reach
"Depletion of USP8 by siRNA enhances HRS ubiquitination and inhibits CXCR4 degradation."
24790097
HGS affects USP8
| 10 7
HGS binds USP8.
| 8 7
USP8 binds HGS. 10 / 10
| 8 2
reach
"In somatic cells, USP8 interacts with the ESCRT-0 machinery [i.e., STAM (signal transducing adaptor molecule) and HGS (hepatocyte growth factor regulated tyrosine kinase substrate)] and its deubiquitinating activity regulates the endosomal sorting of ubiquitinated cargo between the recycling pathway and the lysosomal degradation pathway [XREF_BIBR]."
24709878
reach
"USP8 also interacts with the HRS and STAM complex."
18687060
reach
"Although the interaction between Mop, Cbl, Ubpy, and Hrs seems to play a role in the recycling of Fz, our present findings do not exclude a role for other unidentified proteins in this molecular cascade."
26224310
reach
"In an immunoprecipitation assay, we did not observe a strong physical interaction between Hrs and USP8 (not shown)."
24244405
reach
"Studies have shown that USP8 also interacts with and deubiquitinate Hrs, demonstrating multiple roles of USP8 in both cargo de-ubiquitination and ESCRT-0 stability during development, which is helpful to address the mechanisms of Hh signaling."
26973699
reach
"The human USP8 binds the Hrs binding partner (Hbp) and inhibits EGF receptor (EGFR) endocytosis, suggesting that USP8 may act to regulate endocytic traffic."
40061651
reach
"We provide evidence that Ubpy interacts with and deubiquitylates Hrs."
24574010
sparser
"In an immunoprecipitation assay, we did not observe a strong physical interaction between Hrs and USP8 (not shown)."
24244405
reach
"By binding to STAM and Hrs, USP8 stabilizes the ESCRT-0 complex, which is the crucial element directing ubiquitinated substrates toward MVB/lysosome-mediated degradation (Mizuno et al., 2006; Row et al., 2006)."
39576689
sparser
"A de-ubiquitinating enzyme UBPY interacts with the SH3 domain of Hrs binding protein via a novel binding motif Px(V/I)(D/N)RxxKP."
12176377
HGS binds USP8 and SMO. 2 / 2
| 2
sparser
"It is possible that Hrs competes with USP8 for binding Smo, as Hrs and USP8 directly interact with the same domain of Smo."
24244405
sparser
"However, we found that Hrs blocks Smo phosphorylation ( xref ), whereas USP8 does not xref , suggesting that Hrs and USP8 bind Smo in different conformation."
24244405
HERC4 binds USP8, UCHL5, and HGS. 1 / 1
| 1
sparser
"Herc4 interacts with USP8, UCHL5, and Hrs to regulate Smo ubiquitination."
30925584
STAM binds HGS and USP8. 1 / 1
| 1
sparser
"The Hrs-STAM endosomal sorting complex interacts with UBPY via the Src homology 3 domain of STAM [9] ."
17720156
USP8 binds STAMBP, STAM, and HGS. 1 / 1
| 1
sparser
"UBPY and AMSH interact with the Hrs-STAM complex and counteract ubiquitination of RTKs."
34198477
HGS activates USP8.
| 2
HGS bound to HPSE activates USP8. 1 / 1
| 1
reach
"Remarkably, UBPY is catalytically activated by the HSE1 subunit of the early-acting VPS27–HSE1 complex [ 57 • ]."
18222686
HGS activates USP8. 1 / 1
| 1
reach
"Overexpression of Hrs or a dominant negative mutant of SKD1, proteins that play roles in the endosomal sorting of ubiquitinated receptors, caused the accumulation of endogenous UBPY on exaggerated endosomes."
16120644
OTUB1 binds USP8, RNF128, LRIG1, UBB, Urinary Bladder Neoplasms, STAM2, RNF41, EGFR, RPS27A, and HGS. 1 / 1
| 1
sparser
"We determined a significant interaction between OTUB1 and USP8, RNF128, LRIG1, UBB, UBC, STAM2, RNF41, EGFR, RPS27A, and HGS by PPI."
33240928