IndraLab

Statements

USP8 binds HGS. 10 / 10
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reach
"In somatic cells, USP8 interacts with the ESCRT-0 machinery [i.e., STAM (signal transducing adaptor molecule) and HGS (hepatocyte growth factor regulated tyrosine kinase substrate)] and its deubiquitinating activity regulates the endosomal sorting of ubiquitinated cargo between the recycling pathway and the lysosomal degradation pathway [XREF_BIBR]."
24709878
reach
"USP8 also interacts with the HRS and STAM complex."
18687060
reach
"Although the interaction between Mop, Cbl, Ubpy, and Hrs seems to play a role in the recycling of Fz, our present findings do not exclude a role for other unidentified proteins in this molecular cascade."
26224310
reach
"In an immunoprecipitation assay, we did not observe a strong physical interaction between Hrs and USP8 (not shown)."
24244405
reach
"Studies have shown that USP8 also interacts with and deubiquitinate Hrs, demonstrating multiple roles of USP8 in both cargo de-ubiquitination and ESCRT-0 stability during development, which is helpful to address the mechanisms of Hh signaling."
26973699
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"The human USP8 binds the Hrs binding partner (Hbp) and inhibits EGF receptor (EGFR) endocytosis, suggesting that USP8 may act to regulate endocytic traffic."
40061651
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"We provide evidence that Ubpy interacts with and deubiquitylates Hrs."
24574010
sparser
"In an immunoprecipitation assay, we did not observe a strong physical interaction between Hrs and USP8 (not shown)."
24244405
reach
"By binding to STAM and Hrs, USP8 stabilizes the ESCRT-0 complex, which is the crucial element directing ubiquitinated substrates toward MVB/lysosome-mediated degradation (Mizuno et al., 2006; Row et al., 2006)."
39576689
sparser
"A de-ubiquitinating enzyme UBPY interacts with the SH3 domain of Hrs binding protein via a novel binding motif Px(V/I)(D/N)RxxKP."
12176377