IndraLab

Statements

USP42 binds TP53.
3 | 2 5
TP53 binds USP42. 8 / 10
3 | 2 3
reach
"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation ."
31745110
reach
"It has been reported that USP42 interacts with and deubiquitinates p53."
24143256
biogrid
No evidence text available
22085928
sparser
"USP42 forms a direct complex with p53 and controls level of ubiquitination during the early phase of the response to a range of stress signals including Dox [ xref ].."
24143256
biogrid
No evidence text available
22085928
sparser
"USP42 forms a direct complex with p53 and controls level of ubiquitination during the early phase of the response to a range of stress signals."
22085928
sparser
"Usp42 forms a direct complex with p53 and controls its activation in response to cellular stress; as a result it regulates p53-dependent transcription and cell cycle arrest."
25962961
biogrid
No evidence text available
22085928
TP53 binds USP10, USP4, USP7, and USP42. 1 / 1
| 1
sparser
"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."
30497519
TP53 binds USP10, USP7, and USP42. 1 / 1
| 1
sparser
"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation xref – xref ."
31745110
USP42 deubiquitinates TP53.
1 | 6
USP42 deubiquitinates TP53. 7 / 7
1 | 6
reach
"It has been reported that USP42 interacts with and deubiquitinates p53."
24143256
reach
"In the initial phases of a stress response, USP42 deubiquitinates p53 by forming a direct complex with p53."
29479529
reach
"During the early phase of response to a stress signal, USP42 preferentially makes up a complex with and deubiquitinates p53, leading to the rapid activation of p53 for cell cycle arrest and p53-dependent transcription [55]."
| PMC
ubibrowser
"Review"
28801249
reach
"P53 can be directly deubiquitinated by Usp42 which reverses its ubiquitination by MDM2 [XREF_BIBR]."
25962961
reach
"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation ."
31745110
reach
"This is accomplished by several deubiquitination enzymes including USP7 that deubiquitinates Mdm2 to stabilize p53 [XREF_BIBR] as well as USP10 and USP42 that can directly deubiquitinate p53 upon DNA damage [XREF_BIBR, XREF_BIBR]."
28208785
USP42 activates TP53.
| 3 1
USP42 activates TP53. 4 / 4
| 3 1
reach
"Our previous work showed that USP42 can target p53 for deubiquitylation, with depletion of USP42 resulting in delays in stabilization of p53 and recruitment of p53 to target gene promoters."
25336640
sparser
"Importantly though, USP42-dependent activation of p53 does not lead to apoptosis, suggesting that its main function is to contribute to the repair and recovery of cells from mild or transient damage."
32201366
reach
"USP42 itself was reported to increase the stability of p53 [XREF_BIBR]."
24646765
reach
"Although we do not find a clear role for USP42 in controlling either the basal or fully activated levels of p53, the function of USP42 is required to allow the rapid activation of p53 dependent transcription and a p53 dependent cell-cycle arrest in response to stress."
22085928