IndraLab

Statements

ATXN7 affects USP22
8 | 5 2
ATXN7 binds USP22.
8 | 1 2
ATXN7 binds USP22. 9 / 10
8 | 1
biogrid
No evidence text available
26195632
reach
"Western blot analysis of complexes obtained after an ATXN7 immunopurification showed that USP22 and ATXN7L3 associate with ATXN7 together with other components of TFTC and STAGA."
18206972
biogrid
No evidence text available
18206972
biogrid
No evidence text available
18206973
biogrid
No evidence text available
21746879
biogrid
No evidence text available
26195632
biogrid
No evidence text available
26195632
biogrid
No evidence text available
19843541
biogrid
No evidence text available
18206972
ATXN7 binds USP22, ENY2, and ATXN7L3. 1 / 1
| 1
sparser
"Like yeast Ubp8, USP22 also forms a DUBm complex with the human orthologue ATXN7L3, ENY2 and ATXN7 and functions as a DUB unit of the human SAGA complex[ xref , xref ]."
34660907
ATXN7 binds USP22 and ATXN7L3. 1 / 1
| 1
sparser
"Western blot analysis of complexes obtained after an ATXN7 immunopurification showed that USP22 and ATXN7L3 associate with ATXN7 together with other components of TFTC/STAGA ( Figure 1 D, lane 4)."
18206972
ATXN7 inhibits USP22.
| 4
ATXN7 inhibits USP22. 3 / 4
| 3
reach
"Recently, Lan et al. reported that poly (Q) Ataxin-7 does not directly decrease USP22 enzymatic activity, but instead, it forms aggregates that impair USP22 binding to its substrates [XREF_BIBR]."
27057639
reach
"For example, polyQ ataxin-7 sequesters USP22 into aggregates and inhibits its DUB activity."
28381987
reach
"This indicated that poly (Q) Ataxin-7 likely decreased USP22 activity."
27057639
Mutated ATXN7 inhibits USP22. 1 / 1
| 1
reach
"As the Ubp8 ortholog USP22 was recently shown to interact with, deubiquitinate, and stabilize the Sir2 ortholog Sirt1, and conversely Sirt1 has been shown to mediate deacetylation of USP22 and the SAGA coactivator complex, the discovery of genetic and functional relationships between Sgf73, Ubp8, and Sir2 in yeast strongly suggests that mutant ataxin-7 protein could be impairing the function of not only Gcn5 in the context of the STAGA complex, but also USP22 in the deubiquitinase module."
25043177
USP22 affects ATXN7
8 | 2 2
USP22 binds ATXN7.
8 | 1 2
ATXN7 binds USP22. 9 / 10
8 | 1
biogrid
No evidence text available
26195632
reach
"Western blot analysis of complexes obtained after an ATXN7 immunopurification showed that USP22 and ATXN7L3 associate with ATXN7 together with other components of TFTC and STAGA."
18206972
biogrid
No evidence text available
18206972
biogrid
No evidence text available
18206973
biogrid
No evidence text available
21746879
biogrid
No evidence text available
26195632
biogrid
No evidence text available
26195632
biogrid
No evidence text available
19843541
biogrid
No evidence text available
18206972
ATXN7 binds USP22, ENY2, and ATXN7L3. 1 / 1
| 1
sparser
"Like yeast Ubp8, USP22 also forms a DUBm complex with the human orthologue ATXN7L3, ENY2 and ATXN7 and functions as a DUB unit of the human SAGA complex[ xref , xref ]."
34660907
ATXN7 binds USP22 and ATXN7L3. 1 / 1
| 1
sparser
"Western blot analysis of complexes obtained after an ATXN7 immunopurification showed that USP22 and ATXN7L3 associate with ATXN7 together with other components of TFTC/STAGA ( Figure 1 D, lane 4)."
18206972
USP22 deubiquitinates ATXN7.
| 1
USP22 deubiquitinates ATXN7. 1 / 1
| 1
reach
"While the role of altered STAGA and USP22 deubiquitination complex function in SCA7 disease pathogenesis is unclear, recent studies of the related polyQ disorder SCA1 indicate that the polyQ expansion in ataxin-1 attenuates the formation and function of the Capicua transcription factor complex, contributing to SCA1 disease pathogenesis through a partial loss-of-function mechanism."
21689595