IndraLab

Statements

ATXN7 inhibits USP22. 3 / 4
| 3
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"Recently, Lan et al. reported that poly (Q) Ataxin-7 does not directly decrease USP22 enzymatic activity, but instead, it forms aggregates that impair USP22 binding to its substrates [XREF_BIBR]."
27057639
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"For example, polyQ ataxin-7 sequesters USP22 into aggregates and inhibits its DUB activity."
28381987
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"This indicated that poly (Q) Ataxin-7 likely decreased USP22 activity."
27057639