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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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ATXN7 inhibits USP22. 3 / 4

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"Recently, Lan et al. reported that poly (Q) Ataxin-7 does not directly decrease USP22 enzymatic activity, but instead, it forms aggregates that impair USP22 binding to its substrates [XREF_BIBR]."

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"For example, polyQ ataxin-7 sequesters USP22 into aggregates and inhibits its DUB activity."

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"This indicated that poly (Q) Ataxin-7 likely decreased USP22 activity."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

ATXN7 inhibits USP22. 3 / 4

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