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Mutated ATXN7 inhibits USP22. 1 / 1

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"As the Ubp8 ortholog USP22 was recently shown to interact with, deubiquitinate, and stabilize the Sir2 ortholog Sirt1, and conversely Sirt1 has been shown to mediate deacetylation of USP22 and the SAGA coactivator complex, the discovery of genetic and functional relationships between Sgf73, Ubp8, and Sir2 in yeast strongly suggests that mutant ataxin-7 protein could be impairing the function of not only Gcn5 in the context of the STAGA complex, but also USP22 in the deubiquitinase module."

25043177

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IndraLab

Statements

Mutated ATXN7 inhibits USP22. 1 / 1

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