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USP22 deubiquitinates ATXN7. 1 / 1

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"While the role of altered STAGA and USP22 deubiquitination complex function in SCA7 disease pathogenesis is unclear, recent studies of the related polyQ disorder SCA1 indicate that the polyQ expansion in ataxin-1 attenuates the formation and function of the Capicua transcription factor complex, contributing to SCA1 disease pathogenesis through a partial loss-of-function mechanism."

21689595

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USP22 deubiquitinates ATXN7. 1 / 1

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