IndraLab

Statements

USP18 affects IFNAR
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USP18 inhibits IFNAR.
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USP18 inhibits IFNAR. 6 / 6
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"For example, USP18 is known to prevent IFNAR activation as shown by Honke et al. where USP-18 secreting CD169 macrophages displayed a lower type I IFN sensitivity upon viral infection [38], [57].4 Strategies to control innate immune activation upon conventional and self-amplifying mRNA delivery."
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"In addition to removing ISG15 conjugates, USP18 also limits IFN signaling by preventing dimerization of IFNAR subunits (17)."
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"In addition, independent of its enzymatic activity, USP18 can inhibit the type 1 interferon (IFN-1) signal transduction by binding the Interferon-alpha/beta receptor (IFNAR2) [18]."
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"For example , USP18 is known to prevent IFNAR activation as shown by Honke et al. where USP-18 secreting CD169 + macrophages displayed a lower type I IFN sensitivity upon viral infection [ 38 ] , [ 57 ] ."
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"More specifically USP18 competes with JAK1 for binding to IFNAR2, disrupting the stabilization of cytosolic IFNAR signaling complexes."
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"Similarly, mutations in USP18 gene, that limits IFNAR signaling, leads to an Aicardi‐Goutières syndrome‐like syndrome, known as pseudo‐toxoplasmosis, rubella, cytomegalovirus and herpes syndrome [56]."
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USP18 binds IFNAR.
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USP18 binds IFNAR. 4 / 5
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"In this case, STAT2 was able to bind USP18, but USP18 interaction with IFNAR was impaired, leading to prolonged type I IFN signaling (49)."
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"In this case, STAT2 was able to bind USP18, but USP18 interaction with IFNAR was impaired, leading to prolonged type I IFN signaling ( xref )."
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"They further demonstrated that white matter microglia from mice with a different point mutation disrupting the interaction between USP18 and IFNAR showed prolonged STAT1 activation mirroring the interferon signaling findings in the USP18 KO mice [XREF_BIBR]."
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"What are the host determinants for ISG15’s species-specific effect on the IFNAR–USP18 axis?"
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USP18 activates IFNAR.
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USP18 activates IFNAR. 1 / 1
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"Thus, although CD169+ macrophages in both spleen and LN preferentially allow VSV replication, whether Usp18 mediates downmodulation of IFNAR signaling in LN SCS macrophages needs to be examined to complete the circuit."
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USP18 affects IFNAR1
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USP18 binds IFNAR1.
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USP18 binds IFNAR1. 3 / 3
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"Usp18 can directly activate the JAK/STAT signaling pathway to promote IFN responses [ xref ] or may bind to interferon receptor 2 (IFNAR2) and inhibit the JAK/STAT [ xref ]."
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"Interestingly, USP18 in humans (but not in mice) can also interfere with the anti-viral outcome of IFN signaling by an additional mechanism: USP18 can bind the interferon receptor 2 (IFNAR2), block the association of JAK, and possibly limit IFNAR2-IFNAR1 dimerization, thereby interfering with the JAK-STAT signaling pathway xref ."
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"Their study showed that USP18 does not interact with IFNAR1, but with Box1-Box2 region of IFNAR2 to disrupt its interaction with JAK to inhibit JAK’s tyrosine kinase activity in a DUB activity independent manner [ xref ]."
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USP18 binds IFNAR1 and JAK1. 1 / 1
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"Usp18 (UBP43) binds to the Jak1 binding site of the type I interferon receptor and inhibits its phosphorylation xref ."
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IFNAR1 binds IFNGR1 and USP18. 1 / 1
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"Furthermore, Usp18 functions in the type I IFN pathway by down-regulating the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway independently of its isopeptidase activity through an interaction between Usp18 and the IFNAR2 subunit of the type I IFN receptor complex, while neither IFNAR1 nor IFNGR1 (type II IFN) receptor subunits were able to interact with Usp18 ( xref )."
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USP18 activates IFNAR1.
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USP18 activates IFNAR1. 1 / 1
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"Therefore, the presence of USP18 would reduce the dose–response curve of IFNα — the ligand with lower affinity to IFNAR1 — rather than the one elicited by IFNβ."
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IFNAR affects USP18
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USP18 binds IFNAR. 4 / 5
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"In this case, STAT2 was able to bind USP18, but USP18 interaction with IFNAR was impaired, leading to prolonged type I IFN signaling (49)."
37126806
sparser
"In this case, STAT2 was able to bind USP18, but USP18 interaction with IFNAR was impaired, leading to prolonged type I IFN signaling ( xref )."
37126806
reach
"They further demonstrated that white matter microglia from mice with a different point mutation disrupting the interaction between USP18 and IFNAR showed prolonged STAT1 activation mirroring the interferon signaling findings in the USP18 KO mice [XREF_BIBR]."
28540600
sparser
"What are the host determinants for ISG15’s species-specific effect on the IFNAR–USP18 axis?"
37573184
USP18 affects JAK1
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USP18 binds IFNAR1 and JAK1. 1 / 1
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"Usp18 (UBP43) binds to the Jak1 binding site of the type I interferon receptor and inhibits its phosphorylation xref ."
24204252
USP18 affects IFNGR1
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IFNAR1 binds IFNGR1 and USP18. 1 / 1
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"Furthermore, Usp18 functions in the type I IFN pathway by down-regulating the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway independently of its isopeptidase activity through an interaction between Usp18 and the IFNAR2 subunit of the type I IFN receptor complex, while neither IFNAR1 nor IFNGR1 (type II IFN) receptor subunits were able to interact with Usp18 ( xref )."
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JAK1 affects USP18
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USP18 binds IFNAR1 and JAK1. 1 / 1
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"Usp18 (UBP43) binds to the Jak1 binding site of the type I interferon receptor and inhibits its phosphorylation xref ."
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IFNGR1 affects USP18
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IFNAR1 binds IFNGR1 and USP18. 1 / 1
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"Furthermore, Usp18 functions in the type I IFN pathway by down-regulating the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway independently of its isopeptidase activity through an interaction between Usp18 and the IFNAR2 subunit of the type I IFN receptor complex, while neither IFNAR1 nor IFNGR1 (type II IFN) receptor subunits were able to interact with Usp18 ( xref )."
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IFNAR1 affects JAK1, and USP18
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USP18 binds IFNAR1 and JAK1. 1 / 1
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"Usp18 (UBP43) binds to the Jak1 binding site of the type I interferon receptor and inhibits its phosphorylation xref ."
24204252
IFNAR1 affects IFNGR1, and USP18
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IFNAR1 binds IFNGR1 and USP18. 1 / 1
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sparser
"Furthermore, Usp18 functions in the type I IFN pathway by down-regulating the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway independently of its isopeptidase activity through an interaction between Usp18 and the IFNAR2 subunit of the type I IFN receptor complex, while neither IFNAR1 nor IFNGR1 (type II IFN) receptor subunits were able to interact with Usp18 ( xref )."
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