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USP18 inhibits IFNAR1. 6 / 6
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"Lacking of USP18 leads to an increase signaling of IFN-I, IFN-III, TNF-α and high levels of conjugated ISG15Figure 3: Role of USP18-dependent enforced viral replication in activation of the adaptive immune system and onset of diabetes mellitus type I. (a) USP18 inhibits IFNAR signaling, which leads to enforced viral replication in CD169+ macrophages."
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"For example, USP18 is known to prevent IFNAR activation as shown by Honke et al. where USP-18 secreting CD169+ macrophages displayed a lower type I IFN sensitivity upon viral infection [38], [57]."
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"For example, USP18 is known to prevent IFNAR activation as shown by Honke et al. where USP-18 secreting CD169 macrophages displayed a lower type I IFN sensitivity upon viral infection [38], [57].4 Strategies to control innate immune activation upon conventional and self-amplifying mRNA delivery."
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"For example, USP18 is known to prevent IFNAR activation as shown by Honke et al. where USP-18 secreting CD169 + macrophages displayed a lower type I IFN sensitivity upon viral infection [38, 57] .4."
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"For example , USP18 is known to prevent IFNAR activation as shown by Honke et al. where USP-18 secreting CD169 + macrophages displayed a lower type I IFN sensitivity upon viral infection [ 38 ] , [ 57 ] ."
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"Th17 cells are widely Figure 3 Role of USP18-dependent enforced viral replication in activation of the adaptive immune system and onset of diabetes mellitus type I. (a) USP18 inhibits IFNAR signaling, which leads to enforced viral replication in CD169 + macrophages."
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