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USP18 inhibits IFNAR. 6 / 6
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"For example, USP18 is known to prevent IFNAR activation as shown by Honke et al. where USP-18 secreting CD169 macrophages displayed a lower type I IFN sensitivity upon viral infection [38], [57].4 Strategies to control innate immune activation upon conventional and self-amplifying mRNA delivery."
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"In addition to removing ISG15 conjugates, USP18 also limits IFN signaling by preventing dimerization of IFNAR subunits (17)."
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"In addition, independent of its enzymatic activity, USP18 can inhibit the type 1 interferon (IFN-1) signal transduction by binding the Interferon-alpha/beta receptor (IFNAR2) [18]."
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"For example , USP18 is known to prevent IFNAR activation as shown by Honke et al. where USP-18 secreting CD169 + macrophages displayed a lower type I IFN sensitivity upon viral infection [ 38 ] , [ 57 ] ."
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"More specifically USP18 competes with JAK1 for binding to IFNAR2, disrupting the stabilization of cytosolic IFNAR signaling complexes."
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"Similarly, mutations in USP18 gene, that limits IFNAR signaling, leads to an Aicardi‐Goutières syndrome‐like syndrome, known as pseudo‐toxoplasmosis, rubella, cytomegalovirus and herpes syndrome [56]."
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