IndraLab

Statements

INO80 affects UCHL5
7 | 12 17
INO80 binds UCHL5.
7 | 6 17
INO80 binds UCHL5. 10 / 28
7 | 5 16
sparser
"Further studies have suggested that UCH37 is associated with the human Ino80 chromatin-remodeling complex (hINO80) in the nucleus and can be activated via transient association of 19S regulatory parti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23220010
sparser
"In the nucleus, UCHL5 is also associated with human Ino80 chromatin-remodeling complex and kept in inactive state, and then activated by transient interaction of the Ino80 complex with proteasome, suggesting that it may cooperate to regulate transcription or DNA repair xref ."
23285140
sparser
"And UCH-L5 also interacts with NFRKB in INO80 complex, but it remains unknown that whether UCH-L5 interacts with other components of INO80 complex or not."
29371935
biogrid
No evidence text available
24981860
biogrid
No evidence text available
28598414
sparser
"Recent studies have suggested that in the nucleus UCH37 is also associated with the human Ino80 chromatin-remodeling complex (hINO80), and that it binds to hINO80 via its C-terminal tail and N-termina[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20302916
sparser
"With respect to genome stability, the role of UCHL5 is to remove polyUb chains, and subsequent degradation, of NFRKB (nuclear factor related to kB-binding protein), a factor known to promote the interaction between UCHL5 and INO80 ( xref )."
38572758
sparser
"Considering that INO80 functions in transcription and DNA repair through chromatin remodeling [ xref ], histones and transcription factors are among likely candidates for substrates of INO80-bound Uch37."
28988953
sparser
"Thus, it is assumed that in the nucleus UCH37 interacts with two complexes, the 19S proteasome regulatory particle and hINO80 complex [36,37] ."
20302916
biogrid
No evidence text available
28514442
INO80 binds UCHL5 and ULD domain. 1 / 1
| 1
reach
"Both RPN13 DEU and INO80 DEU primarily bind the C-terminal ULD domain of UCH-L5, but are positioned radically differently relative to the UCH-L5 CD, which itself hardly changes conformation among all UCH-L5 structures."
25702870
UCHL5 binds Proteasome and INO80. 1 / 1
| 1
sparser
"UCHL5 is associated with both the proteasome and the INO80 chromatin remodeling complex, and functions in both contexts [ xref ]."
31703099
INO80 activates UCHL5.
| 4
INO80 activates UCHL5. 4 / 4
| 4
reach
"Curiously, INO80 associated UCH37 can be activated by transient incubation with either RPN13 or 26S proteasome lacking UCH37, without UCH37 dissociating from the INO80 complex."
25702872
reach
"In the nucleus, UCHL5 is also associated with human Ino80 chromatin remodeling complex and kept in inactive state, and then activated by transient interaction of the Ino80 complex with proteasome, suggesting that it may cooperate to regulate transcription or DNA repair XREF_BIBR."
23285140
reach
"Intriguingly, Uch37 is held in an inactive state in the INO80 complex but, at least in vitro, can be activated by transient interaction of the INO80 complex with proteasomes [26]."
19062292
reach
"A possibility is that INO80 controls UCH-L5 in a temporal manner, where in some circumstances UCH-L5 is inhibited while under other circumstances post-translational modifications (PTMs) and/or conformational changes release the inhibition and activate UCH-L5, allowing for additional layers of regulation."
25702870
INO80 inhibits UCHL5.
| 2
INO80 inhibits UCHL5. 2 / 2
| 2
reach
"This suggests the INO80 complex could potentially inactivate all activities of UCH37."
35451368
reach
"The essential cysteine protease UCH-L5 is activated by proteasome ubiquitin receptor RPN13 (ADRM1) or inhibited by chromatin remodeling complex component INO80 (NFRKB) [XREF_BIBR]."
29371935
UCHL5 affects INO80
7 | 8 17
UCHL5 binds INO80.
7 | 6 17
INO80 binds UCHL5. 10 / 28
7 | 5 16
sparser
"Further studies have suggested that UCH37 is associated with the human Ino80 chromatin-remodeling complex (hINO80) in the nucleus and can be activated via transient association of 19S regulatory parti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23220010
sparser
"In the nucleus, UCHL5 is also associated with human Ino80 chromatin-remodeling complex and kept in inactive state, and then activated by transient interaction of the Ino80 complex with proteasome, suggesting that it may cooperate to regulate transcription or DNA repair xref ."
23285140
sparser
"And UCH-L5 also interacts with NFRKB in INO80 complex, but it remains unknown that whether UCH-L5 interacts with other components of INO80 complex or not."
29371935
biogrid
No evidence text available
24981860
biogrid
No evidence text available
28598414
sparser
"Recent studies have suggested that in the nucleus UCH37 is also associated with the human Ino80 chromatin-remodeling complex (hINO80), and that it binds to hINO80 via its C-terminal tail and N-termina[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20302916
sparser
"With respect to genome stability, the role of UCHL5 is to remove polyUb chains, and subsequent degradation, of NFRKB (nuclear factor related to kB-binding protein), a factor known to promote the interaction between UCHL5 and INO80 ( xref )."
38572758
sparser
"Considering that INO80 functions in transcription and DNA repair through chromatin remodeling [ xref ], histones and transcription factors are among likely candidates for substrates of INO80-bound Uch37."
28988953
sparser
"Thus, it is assumed that in the nucleus UCH37 interacts with two complexes, the 19S proteasome regulatory particle and hINO80 complex [36,37] ."
20302916
biogrid
No evidence text available
28514442
INO80 binds UCHL5 and ULD domain. 1 / 1
| 1
reach
"Both RPN13 DEU and INO80 DEU primarily bind the C-terminal ULD domain of UCH-L5, but are positioned radically differently relative to the UCH-L5 CD, which itself hardly changes conformation among all UCH-L5 structures."
25702870
UCHL5 binds Proteasome and INO80. 1 / 1
| 1
sparser
"UCHL5 is associated with both the proteasome and the INO80 chromatin remodeling complex, and functions in both contexts [ xref ]."
31703099
UCHL5 deubiquitinates INO80.
| 1
UCHL5 deubiquitinates INO80. 1 / 1
| 1
reach
"UCHL5 is also required for BLM/EXO1 dependent end resection through de-ubiquitinating the INO80 subunit NFRKB, although the function of this subunit in regulating end resection is not currently understood [37]."
31769469
UCHL5 activates INO80.
| 1
UCHL5 activates INO80. 1 / 1
| 1
reach
"And finally, what genes are targeted by Uch37 containing INO80?"
18922460
ACTL6A binds TFPT, YY1, INO80D, NFRKB, INO80C, INO80E, MCRS1, INO80B, ACTR8, ACTR5, INO80, RUVBL2, RUVBL1, and UCHL5. 1 / 1
1 |
signor
"Inferred from SIGNOR complex SIGNOR-C498"