IndraLab

Statements

INO80 activates UCHL5. 4 / 4
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"Curiously, INO80 associated UCH37 can be activated by transient incubation with either RPN13 or 26S proteasome lacking UCH37, without UCH37 dissociating from the INO80 complex."
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"In the nucleus, UCHL5 is also associated with human Ino80 chromatin remodeling complex and kept in inactive state, and then activated by transient interaction of the Ino80 complex with proteasome, suggesting that it may cooperate to regulate transcription or DNA repair XREF_BIBR."
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"Intriguingly, Uch37 is held in an inactive state in the INO80 complex but, at least in vitro, can be activated by transient interaction of the INO80 complex with proteasomes [26]."
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"A possibility is that INO80 controls UCH-L5 in a temporal manner, where in some circumstances UCH-L5 is inhibited while under other circumstances post-translational modifications (PTMs) and/or conformational changes release the inhibition and activate UCH-L5, allowing for additional layers of regulation."
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