IndraLab

Statements

INO80 binds UCHL5. 28 / 28
7 | 5 16
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"Further studies have suggested that UCH37 is associated with the human Ino80 chromatin-remodeling complex (hINO80) in the nucleus and can be activated via transient association of 19S regulatory parti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23220010
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"In the nucleus, UCHL5 is also associated with human Ino80 chromatin-remodeling complex and kept in inactive state, and then activated by transient interaction of the Ino80 complex with proteasome, suggesting that it may cooperate to regulate transcription or DNA repair xref ."
23285140
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"And UCH-L5 also interacts with NFRKB in INO80 complex, but it remains unknown that whether UCH-L5 interacts with other components of INO80 complex or not."
29371935
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No evidence text available
24981860
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No evidence text available
28598414
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"Recent studies have suggested that in the nucleus UCH37 is also associated with the human Ino80 chromatin-remodeling complex (hINO80), and that it binds to hINO80 via its C-terminal tail and N-termina[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20302916
sparser
"With respect to genome stability, the role of UCHL5 is to remove polyUb chains, and subsequent degradation, of NFRKB (nuclear factor related to kB-binding protein), a factor known to promote the interaction between UCHL5 and INO80 ( xref )."
38572758
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"Considering that INO80 functions in transcription and DNA repair through chromatin remodeling [ xref ], histones and transcription factors are among likely candidates for substrates of INO80-bound Uch37."
28988953
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"Thus, it is assumed that in the nucleus UCH37 interacts with two complexes, the 19S proteasome regulatory particle and hINO80 complex [36,37] ."
20302916
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No evidence text available
28514442
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"Yao et al. xref demonstrated that Uch37 also associates with the Ino80 chromatin-remodeling complex (Ino80 complex), which is involved in DNA repair and transcriptional regulation."
21953935
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"For example, as mentioned above, certain transcriptional activators are ubiquitylated to regulate their stability or activity and INO80 bound Uch37 could regulate transcription through these mediators."
18922460
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"Considering that INO80 functions in transcription and DNA repair through chromatin remodeling [65], histones and transcription factors are among likely candidates for substrates of INO80 bound Uch37."
28988953
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"The transient association of the INO80 complex with UCH37 regulates the deubiquitylating activity of this subunit."
19424290
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"Here we show that in the nucleus Uch37 is also associated with the human Ino80 chromatin-remodeling complex (hINO80)."
18922472
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"With respect to genome stability, the role of UCHL5 is to remove polyUb chains, and subsequent degradation, of NFRKB (nuclear factor related to kB-binding protein), a factor known to promote the interaction between UCHL5 and INO80 (Figure 2A)."
38572758
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"Uch37 is bound to hINO80 via its C-terminal tail and the N-terminal domain of NFRKB."
18922472
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"It is important to note, however, that although NFRKB was the only hINO80 subunit that interacted with Uch37 in our yeast two-hybrid assays, it is likely that Uch37 interacts with other hINO80 subunits in the context of the intact complex."
18922472
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"For example, as mentioned above, certain transcriptional activators are ubiquitylated to regulate their stability or activity ( xref ) and INO80-bound Uch37 could regulate transcription through these mediators."
18922460
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No evidence text available
33961781
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"Our dissection of interactions between hINO80 and Uch37 shows that one polypeptide, NFRKB, has elements that can inhibit and activate deubiquitinating activity."
18922472
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18922472
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"In contrast, INO80 associated Uch37 or Uch37 in complex with the NFRKB 1-465 fragment is either inhibited (as assessed by UbVS reactivity) or held in a relatively inactive state similar to that of free Uch37 (as assessed by its ability to hydrolyze UbAMC)."
18922472
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"Our dissection of interactions between hINO80 and Uch37 shows that one polypeptide, NFRKB, has elements that can inhibit and activate deubiquitinating activity."
18922472
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"To find the reason for the inhibitory activity, the yeast two-hybrid test was used to screen the 14 human INO80 subunits that directly interact with UCHL5, and the only subunit detected to interact wi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
35093437
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26186194
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"Interestingly, UCH37 also associates in the nucleus with the human Ino80 chromatin-remodeling complex, where it is held in an inactive state compared to the free enzyme( xref )."
23617878
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No evidence text available
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