IndraLab

Statements

COPS6 affects COPS5
23 3 | 31 78
COPS6 binds COPS5.
23 3 | 28 77
COPS5 binds COPS6. 10 / 118
23 3 | 25 66
reach
"Molecular dynamics simulation studies further suggest that heterodimerization of CSN5 with CSN6 facilitates inhibitor binding by stabilizing an open ins-1 loop conformation [ 58 ]."
36041947
hprd
No evidence text available
12220626
hprd
No evidence text available
11285227
reach
"CSN5 and CSN6, which have an MPN (Mpr1 and Pad1 N-terminal) domain, form a dimer and are embedded at the core of the helical bundle."
29616013
reach
"The structure reaffirms the conserved activation mechanism of the deneddylation machinery, including conformational clamping of CRL2 by CSN2/CSN4, release of the catalytic CSN5/CSN6 heterodimer, and s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33271439
sparser
"The above suggests that the MPN dimer (CSN5–CSN6 dimer) could be highly conserved."
33806190
hprd
No evidence text available
11337588
sparser
"Structurally, CSN6 and CSN5 form a heterodimer through MPN domain and the dimer is topologically knotted to engage in Cullin deneddylation xref ."
25395170
sparser
"MD simulations studies and binding energy analysis revealed that the selective binding of the inhibitors can be only explained by the consideration of larger heterodimeric complexes of Rpn11 (Rpn8-Rpn11) and CSN5 (CSN5-CSN6)."
30356695
sparser
"In the crystal structure of CSN5-CSN6 heterodimer, initial Ins-1 loop (98–109) conformation blocks the distal ubiquitin binding site which we also observed in cryo-EM structure of Rpn11."
30356695
COPS6 binds PRSS27 and COPS5. 3 / 3
| 3
sparser
"CSN5 alone is inactive due to an auto-inhibited conformation of its catalytic domain, and the association of CSN5 with the CSN6 MPN (Mpr1/Pad1 N-terminal) domain activates its isopeptidase activity xref ."
27137867
sparser
"The association of CSN5 and CSN6 MPN (for Mpr1/Pad1 N-terminal) domains activates its isopeptidase activity."
25144743
sparser
"Here we report that CSN6 N-terminal domain containing its MPN domain can form a stable heterodimer with CSN5 catalytic domain in vitro ."
25144743
CSN3 binds COPS5 and COPS6. 3 / 3
| 3
sparser
"Our data also demonstrate that CSNAP binds to CSN3, CSN5 and CSN6, possibly linking the MPN and PCI substructures."
26456823
sparser
"We show that CSNAP binds CSN3, CSN5 and CSN6 and its incorporation into the CSN complex is mediated through the C-terminal region involving conserved aromatic residues."
26456823
sparser
"CSNAP interacts with CSN3, CSN5, and CSN6."
26456823
COPS6 binds COPS5 and MPN domain. 2 / 2
| 2
reach
"Structurally, CSN6 and CSN5 form a heterodimer through MPN domain, and the dimer is topologically knotted to engage in Cullin deneddylation."
26267535
reach
"Structurally, CSN6 and CSN5 form a heterodimer through MPN domain and the dimer is topologically knotted to engage in Cullin deneddylation 55."
25395170
COPS6 binds COPS5 and CRL. 1 / 1
| 1
sparser
"Conformational changes of CSN2, CSN4 and CSN7 provide an induced fit mechanism that propagates the binding of neddylated CRL to the CSN5–CSN6 dimer and activates CSN5 [ xref ]."
29249570
RNF139 binds COPS5 and COPS6. 1 / 1
| 1
sparser
"We previously reported that Drosophila Trc8 genetically and physically interacts with Csn5 and Csn6, but not Rpn8 or Rpn11 ( xref )."
20068067
Rpn11 binds RPN8, COPS6, and COPS5. 1 / 1
| 1
sparser
"Considering the Rpn8-Rpn11 and CSN5-CSN6 heterodimers, we found that residues in the distal ubiquitin site are responsible for selectivity and must be taken into consideration for the design of selective inhibitors of CSN5 and Rpn11 in future studies."
30356695
COPS5 binds COPS6 and MPN domains. 1 / 1
| 1
reach
"Having shown that the N-terminal MPN domains of CSN5 and CSN6 heterodimerize, we went on to evaluate the effect of CSN6 DeltaC on CSN5 DeltaC 's affinity for Nedd8 and its isopeptidase activity on substrates ranging from protein to a physiological complex."
25144743
COPS6 binds COPS5 and CSN5i-3. 1 / 1
| 1
sparser
"Binding of capzimin and CSN5i-3 to monomeric CSN5 and CSN5-CSN6 heterodimer."
30356695
COPS6 binds COPS5 and CUL1. 1 / 1
| 1
sparser
"We found that both CSN6 and CSN5 associated with Cullin-1 and that CSN6 and CSN5 competed with each other for Cullin-1 binding in a dose-dependent manner ( xref )."
25395170
COPS6 activates COPS5.
| 1 1
COPS6 activates COPS5. 2 / 3
| 1 1
reach
"Previous study has shown that over-expression of CSN6 increases its competition with CSN5 in terms of cullin binding, and thereby inhibits accessibility of cullin to CSN5 for deneddylation, which stab[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30180991
sparser
"To gain additional insights into the molecular mechanism of CSN5 activation by CSN6, the crystal structure of the MPN − core fragment was determined by molecular replacement at 1.76 Å resolution, using the human Rpn8 ΔC orthologue as the search model (PDB code 2O95; xref )."
25144743
COPS6 inhibits COPS5.
| 2
COPS6 inhibits COPS5. 2 / 2
| 2
reach
"Previous study has shown that over-expression of CSN6 increases its competition with CSN5 in terms of cullin binding, and thereby inhibits accessibility of cullin to CSN5 for deneddylation, which stab[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30180991
reach
"Notably, the MPN domain of CSN6 inhibited the association of CSN5 with Cullin-1, while the C-terminal domain had less impact (XREF_FIG)."
25395170
COPS2 affects COPS3, COPS4, COPS5, COPS6, COPS7A, COPS8, and GPS1
1 2 |
signor
"Inferred from SIGNOR complex SIGNOR-C489"
hprd
No evidence text available
12220626
hprd
No evidence text available
9535219
MPN domain affects COPS6
| 2
COPS6 binds COPS5 and MPN domain. 2 / 2
| 2
reach
"Structurally, CSN6 and CSN5 form a heterodimer through MPN domain, and the dimer is topologically knotted to engage in Cullin deneddylation."
26267535
reach
"Structurally, CSN6 and CSN5 form a heterodimer through MPN domain and the dimer is topologically knotted to engage in Cullin deneddylation 55."
25395170
Rpn11 affects RPN8
| 1
Rpn11 binds RPN8, COPS6, and COPS5. 1 / 1
| 1
sparser
"Considering the Rpn8-Rpn11 and CSN5-CSN6 heterodimers, we found that residues in the distal ubiquitin site are responsible for selectivity and must be taken into consideration for the design of selective inhibitors of CSN5 and Rpn11 in future studies."
30356695
RNF139 affects COPS6
| 1
RNF139 binds COPS5 and COPS6. 1 / 1
| 1
sparser
"We previously reported that Drosophila Trc8 genetically and physically interacts with Csn5 and Csn6, but not Rpn8 or Rpn11 ( xref )."
20068067
MPN domains affects COPS6
| 1
COPS5 binds COPS6 and MPN domains. 1 / 1
| 1
reach
"Having shown that the N-terminal MPN domains of CSN5 and CSN6 heterodimerize, we went on to evaluate the effect of CSN6 DeltaC on CSN5 DeltaC 's affinity for Nedd8 and its isopeptidase activity on substrates ranging from protein to a physiological complex."
25144743
CUL1 affects COPS6
| 1
COPS6 binds COPS5 and CUL1. 1 / 1
| 1
sparser
"We found that both CSN6 and CSN5 associated with Cullin-1 and that CSN6 and CSN5 competed with each other for Cullin-1 binding in a dose-dependent manner ( xref )."
25395170
CSN5i-3 affects COPS6
| 1
COPS6 binds COPS5 and CSN5i-3. 1 / 1
| 1
sparser
"Binding of capzimin and CSN5i-3 to monomeric CSN5 and CSN5-CSN6 heterodimer."
30356695
CRL affects COPS6
| 1
COPS6 binds COPS5 and CRL. 1 / 1
| 1
sparser
"Conformational changes of CSN2, CSN4 and CSN7 provide an induced fit mechanism that propagates the binding of neddylated CRL to the CSN5–CSN6 dimer and activates CSN5 [ xref ]."
29249570
COPS6 affects rpn11
| 1
Rpn11 binds RPN8, COPS6, and COPS5. 1 / 1
| 1
sparser
"Considering the Rpn8-Rpn11 and CSN5-CSN6 heterodimers, we found that residues in the distal ubiquitin site are responsible for selectivity and must be taken into consideration for the design of selective inhibitors of CSN5 and Rpn11 in future studies."
30356695
COPS6 affects RNF139
| 1
RNF139 binds COPS5 and COPS6. 1 / 1
| 1
sparser
"We previously reported that Drosophila Trc8 genetically and physically interacts with Csn5 and Csn6, but not Rpn8 or Rpn11 ( xref )."
20068067
COPS6 affects MPN domains
| 1
COPS5 binds COPS6 and MPN domains. 1 / 1
| 1
reach
"Having shown that the N-terminal MPN domains of CSN5 and CSN6 heterodimerize, we went on to evaluate the effect of CSN6 DeltaC on CSN5 DeltaC 's affinity for Nedd8 and its isopeptidase activity on substrates ranging from protein to a physiological complex."
25144743
COPS6 affects CUL1
| 1
COPS6 binds COPS5 and CUL1. 1 / 1
| 1
sparser
"We found that both CSN6 and CSN5 associated with Cullin-1 and that CSN6 and CSN5 competed with each other for Cullin-1 binding in a dose-dependent manner ( xref )."
25395170
COPS6 affects CSN5i-3
| 1
COPS6 binds COPS5 and CSN5i-3. 1 / 1
| 1
sparser
"Binding of capzimin and CSN5i-3 to monomeric CSN5 and CSN5-CSN6 heterodimer."
30356695
COPS6 affects CRL
| 1
COPS6 binds COPS5 and CRL. 1 / 1
| 1
sparser
"Conformational changes of CSN2, CSN4 and CSN7 provide an induced fit mechanism that propagates the binding of neddylated CRL to the CSN5–CSN6 dimer and activates CSN5 [ xref ]."
29249570
COPS5 affects rpn11
| 1
Rpn11 binds RPN8, COPS6, and COPS5. 1 / 1
| 1
sparser
"Considering the Rpn8-Rpn11 and CSN5-CSN6 heterodimers, we found that residues in the distal ubiquitin site are responsible for selectivity and must be taken into consideration for the design of selective inhibitors of CSN5 and Rpn11 in future studies."
30356695
COPS5 affects RNF139
| 1
RNF139 binds COPS5 and COPS6. 1 / 1
| 1
sparser
"We previously reported that Drosophila Trc8 genetically and physically interacts with Csn5 and Csn6, but not Rpn8 or Rpn11 ( xref )."
20068067
COPS5 affects MPN domains
| 1
COPS5 binds COPS6 and MPN domains. 1 / 1
| 1
reach
"Having shown that the N-terminal MPN domains of CSN5 and CSN6 heterodimerize, we went on to evaluate the effect of CSN6 DeltaC on CSN5 DeltaC 's affinity for Nedd8 and its isopeptidase activity on substrates ranging from protein to a physiological complex."
25144743
COPS5 affects CUL1
| 1
COPS6 binds COPS5 and CUL1. 1 / 1
| 1
sparser
"We found that both CSN6 and CSN5 associated with Cullin-1 and that CSN6 and CSN5 competed with each other for Cullin-1 binding in a dose-dependent manner ( xref )."
25395170
COPS5 affects CSN5i-3
| 1
COPS6 binds COPS5 and CSN5i-3. 1 / 1
| 1
sparser
"Binding of capzimin and CSN5i-3 to monomeric CSN5 and CSN5-CSN6 heterodimer."
30356695
COPS5 affects CRL
| 1
COPS6 binds COPS5 and CRL. 1 / 1
| 1
sparser
"Conformational changes of CSN2, CSN4 and CSN7 provide an induced fit mechanism that propagates the binding of neddylated CRL to the CSN5–CSN6 dimer and activates CSN5 [ xref ]."
29249570
COPS5 affects COPS6, RPN8, and rpn11
| 1
Rpn11 binds RPN8, COPS6, and COPS5. 1 / 1
| 1
sparser
"Considering the Rpn8-Rpn11 and CSN5-CSN6 heterodimers, we found that residues in the distal ubiquitin site are responsible for selectivity and must be taken into consideration for the design of selective inhibitors of CSN5 and Rpn11 in future studies."
30356695
COPS5 affects COPS6, and RNF139
| 1
RNF139 binds COPS5 and COPS6. 1 / 1
| 1
sparser
"We previously reported that Drosophila Trc8 genetically and physically interacts with Csn5 and Csn6, but not Rpn8 or Rpn11 ( xref )."
20068067
COPS5 affects COPS6, and MPN domains
| 1
COPS5 binds COPS6 and MPN domains. 1 / 1
| 1
reach
"Having shown that the N-terminal MPN domains of CSN5 and CSN6 heterodimerize, we went on to evaluate the effect of CSN6 DeltaC on CSN5 DeltaC 's affinity for Nedd8 and its isopeptidase activity on substrates ranging from protein to a physiological complex."
25144743
COPS5 affects COPS6, and CUL1
| 1
COPS6 binds COPS5 and CUL1. 1 / 1
| 1
sparser
"We found that both CSN6 and CSN5 associated with Cullin-1 and that CSN6 and CSN5 competed with each other for Cullin-1 binding in a dose-dependent manner ( xref )."
25395170
COPS5 affects COPS6, and CSN5i-3
| 1
COPS6 binds COPS5 and CSN5i-3. 1 / 1
| 1
sparser
"Binding of capzimin and CSN5i-3 to monomeric CSN5 and CSN5-CSN6 heterodimer."
30356695
COPS5 affects COPS6, and CRL
| 1
COPS6 binds COPS5 and CRL. 1 / 1
| 1
sparser
"Conformational changes of CSN2, CSN4 and CSN7 provide an induced fit mechanism that propagates the binding of neddylated CRL to the CSN5–CSN6 dimer and activates CSN5 [ xref ]."
29249570
COPS2 affects COPS3, COPS4, COPS5, COPS6, COPS7B, COPS8, and GPS1
1 |
COPS2 binds GPS1, COPS6, COPS5, COPS8, COPS4, COPS7B, and COPS3. 1 / 1
1 |
signor
"Inferred from SIGNOR complex SIGNOR-C487"
COPS2 affects COPS3, COPS4, COPS5, COPS6, COPS7A, COPS8, GPS1, and TP53
1 |
TP53 binds COPS2, COPS5, COPS3, COPS4, GPS1, COPS6, COPS7A, and COPS8. 1 / 1
1 |
hprd
No evidence text available
11285227
COPS2 affects COPS3, COPS4, COPS5, COPS6, COPS7A, COPS8, CUL4A, and GPS1
1 |
hprd
No evidence text available
11337588
hprd
No evidence text available
11337588
EEF2 binds SKP1, CUL1, COPS2, RBX1, COPS5, COPS3, FBXO6, COPS4, COPS7B, GPS1, FBXO3, COPS6, COPS7A, and COPS8. 1 / 1
1 |
hprd
No evidence text available
11337588