IndraLab

Statements

COPS6 activates COPS5. 2 / 3
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reach
"Previous study has shown that over-expression of CSN6 increases its competition with CSN5 in terms of cullin binding, and thereby inhibits accessibility of cullin to CSN5 for deneddylation, which stab[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30180991
sparser
"To gain additional insights into the molecular mechanism of CSN5 activation by CSN6, the crystal structure of the MPN − core fragment was determined by molecular replacement at 1.76 Å resolution, using the human Rpn8 ΔC orthologue as the search model (PDB code 2O95; xref )."
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