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CYLD inhibits TLR. 4 / 4
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"However, a more recent study has shown that CYLD inhibits TLR signaling by deubiquitinating NTHi induced K63 linked polyubiquitination of MyD88 at lysine 231 [181]."
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"Meanwhile, the deubiquitinases CYLD and OTUD4 have been revealed as able to cleave K63-linked polyubiquitination of MyD88 and thus to deactivate TLR-mediated NF-κB signaling (11, 12)."

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"However, a more recent study has shown that CYLD inhibits TLR signaling by deubiquitinating NTHi-induced K63-linked polyubiquitination of MyD88 at lysine 231 [181] ."

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"On the other hand, whereas CYLD was previously reported to inhibit TLR and RLR pathways ( Friedman et al., 2008; Yoshida et al., 2005; Zhang et al., 2008 ), recently CYLD has been shown to be vital fo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"