IndraLab

Statements

COPS5 activates Neoplasms. 12 / 12
| 1 11
reach
"Animal studies have verified that troglitazone decreases Jab1/CSN5 expression and suppresses HCC cell growth in tumor tissues ."
35315259
reach
"As depicted in Figure 1G-I, knockdown of CSN5 markedly inhibited tumor growth in the nude mice."
38385070
reach
"Among them, COPS5 was associated with p53 [ 23 ] and promoted tumor progression by degrading p53 [ 24 ]."
36100071
reach
"For instance, as an oncogene, it remains unclear whether exogenous upregulation of JAB1 may increase the risk of tumor development."
37365502
reach
"Therefore, it is important to identify novel biomarkers that can predict the clinical outcome of NPC and to investigate the molecules involved in tumor progression for patient treatment.Previous studies have shown that the expression level of Jab1 is elevated in many tumors, including NPC (16), which is consistent with the findings of our study."
36618352
reach
"Systemic delivery of the modified Jab1/CSN5 3/8 variant siRNA encapsulated in SNALP remarkably inhibited hepatic tumor growth in an orthotopic xenograft model of human liver cancer ( Lee et al., 2011 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30468907
reach
"Taken together, these results illustrated that the tumor-promoting effects of CSN5 in OS is partially dependent on EGFR enhancement.CSN5, as a critical subunit of the COP9 signalosome, has been report[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31560888
eidos
"Previous research by Wang et al. has shown that JAB1 promotes the progression of malignancies ."
32064781
reach
"CSN5 can induce degradation of several tumor suppressors (eg, p27, p53, NCoR) and stabilize oncogenes (eg, MDM2, BCL2, Snail) in various cancer cell types (16)."
34802033
reach
"Notably, COPS5 promoted tumor progression by degrading p53 [ 24 ]."
36100071
reach
"Basically, JAB1 promotes tumor development by propelling cell cycle progression, impairing DNA repair response, regulating cell apoptosis and proliferation, which has been extensively discussed in several reviews (Shackleford and Claret 2010; Pan et al. 2014; Guo et al. 2019; Yuan et al. 2021)."
37365502
reach
"First, curcumin restrains CSN5-associated kinase activity (15, 20), and therefore, curcumin can inhibit many tumor processes caused by CSN5 activity in cancer cells, such as cell survival, proliferati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31991125