IndraLab

Statements

reach
"Hydroxychloroquine increased cholesterol transfer to high-density lipoprotein in systemic lupus erythematosus: A possible mechanism for the reversal of atherosclerosis in the disease."
35332823
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"However, hydroxychloroquine, one of two tested s-Et 3 N drugs at a cytostatic concentration (50 muM), increased total and free cholesterol over 48 h; procainamide (2.5 mM) was inactive in this respect[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27288732
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"The present study is the first to demonstrate that HCQ promoted a higher transfer of unesterified cholesterol which may account for the increased HDL levels in lupus patients under HCQ."
35332823
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"In contrast to remdesivir, HCQ robustly upregulates cholesterol metabolism, autophagy, and starvation pathways and decreases rRNA and tRNA production across all cell lines (XREF_SUPPLEMENTARY), consistent with the known HCQ mechanism of impairment of endosome to lysosome processing XREF_BIBR, XREF_BIBR and suggesting that RNA-seq analysis highlights specific drug response pathways."
32869031
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"We also showed that HCQ decreases the intracellular pH in mature osteoclasts and stimulates cholesterol uptake, suggesting that HCQ induces osteoclastic lysosomal membrane permeabilization (LMP) leading to decreased resorption without changes in apoptosis."
28556961
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"In contrast to remdesivir, HCQ robustly upregulates cholesterol metabolism, autophagy, and starvation pathways and decreases rRNA and tRNA production across all cell lines, consistent with the known HCQ mechanism of impairment of endosome to lysosome processing 19, 26 and suggesting that RNA-seq analysis highlights specific drug response pathways."
32869031
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"As HCQ up-regulates the cholesterol synthesis pathway, we have been suggested that SIM (a cholesterol synthesis inhibitor) would antagonize the inhibitory effects of HCQ on osteoblast differentiation and mineralization."
28975700
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"Continuous HCQ treatment significantly decreases intracellular pH and significantly enhanced cholesterol uptake in mature osteoclasts along with increased expression of the lowdensity lipoprotein receptor."
28556961
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"Improvement of serum cholesterol in patients treated with hydroxychloroquine has been reported."
20442820