IndraLab

Statements

SCN5A binds LMNA. 3 / 3
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"Moreover, they have significantly downregulated Na v 1.5 channel expression and increased binding of Lamin A/C to the promoter of SCN5A, the channel's gene."
31118417
sparser
"In laminopathic IPSCs-derived cardiomyocytes carrying the K219T- LMNA mutation, altered action potential, reduced peak sodium current and diminished conduction velocity have been shown and linked to epigenetic downregulation of Nav1.5 sodium channel expression due to increased binding of Lamin A/C to the promoter of SCN5A gene [ xref ]."
33923914
sparser
"These characteristics are considered as “red flags” for LMNA and SCN5A associated disease [ xref ]."
31179125