IndraLab

Statements

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"Consistent with the effect on luciferase expression, LA inhibited IKK2 (EE)-induced cyclo-oxygenase-2 (COX2) expression, suggesting that IKK2 inhibition by LA may be a relevant mechanism that explains its antiinflammatory effects."
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"However, it has been previously reported that LA inhibits the activity of IKK2 (a kinase regulating IκBα phosphorylation and degradation) in a concentration-dependent way, with a half maximal inhibito[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To verify that LA can inhibit IKK2 in living cells, we tested the effect of LA on a constitutively active IKK2 mutant IKK2(EE)-induced NF- κ B-dependent gene expression."
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"Given that IkappaBalpha degradation is regulated by IKK2 dependent phosphorylation, we tested whether LA inhibits IKK2."
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"In addition, acute LA treatment induced HSPs in vitro in L6 muscle cells and prevented the activation of JNK and IKKbeta with stimulants such as anisomycin and TNF-alpha, respectively."
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"LA inhibits IKK2."
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"Consistent with the effect on luciferase expression, LA inhibited IKK2(EE)-induced cyclo-oxygenase-2 (COX2) expression, suggesting that IKK2 inhibition by LA may be a relevant mechanism that explains its antiinflammatory effects."
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"XREF_FIG shows that LA inhibited IKK2 activity concentration-dependently, with a half maximal inhibitory concentration (IC 50) of 0.15 mM (95% CI : 0.09-0.25 mM)."
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"Our data demonstrate that LA inhibited IKK2 in vitro, providing a potential molecular mechanism for the inhibitory effect of LA on NF-kappaB signaling."
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"LA inhibits IKK2."
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"In the present study, we show that (1) LA, but not other tested antioxidants, inhibits NF- κ B activation, (2) LA-induced activation of the PI3-kinase/Akt pathway in HUVECs does not contribute to its effects on NF- κ B inhibition, (3) inhibition of IKK2 by LA may represent an important mechanism by which it mediates inhibitory effects on NF- κ B activation."
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"To verify that LA can inhibit IKK2 in living cells, we tested the effect of LA on a constitutively active IKK2 mutant IKK2 (EE)-induced NF-kappaB-dependent gene expression."
20927568
sparser
"Given that I κ B α degradation is regulated by IKK2-dependent phosphorylation, we tested whether LA inhibits IKK2. xref shows that LA inhibited IKK2 activity concentration-dependently, with a half maximal inhibitory concentration (IC 50 ) of 0.15 mM (95% CI: 0.09–0.25 mM)."
20927568
sparser
"Our data demonstrate that LA inhibited IKK2 in vitro, providing a potential molecular mechanism for the inhibitory effect of LA on NF- κ B signaling."
20927568
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"In the present study, we show that (1) LA, but not other tested antioxidants, inhibits NF-kappaB activation, (2) LA induced activation of the PI3-kinase and Akt pathway in HUVECs does not contribute to its effects on NF-kappaB inhibition, (3) inhibition of IKK2 by LA may represent an important mechanism by which it mediates inhibitory effects on NF-kappaB activation."
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"In transient co-transfection assays of a constitutively active mutant of IkappaB kinase-2 (IKK2), IKK2 (EE), and a NF-kappaB luciferase reporter construct, LA dose-dependently inhibited IKK2 (EE)-induced NF-kappaB activation in addition to inhibiting IKK activity in in vitro assays."
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"A plausible mechanism suggests that lipoic acid mediated induction of heat shock proteins and the subsequent inhibition of JNK and IKKbeta."
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