IndraLab

Statements

USP1 inhibits ID1. 11 / 11
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"USP1 knockdown in osteosarcoma cells caused ID protein destabilization, p53 independent induction of CDKN1A encoding cyclin dependent kinase inhibitor (CDKI) p21, and cell-cycle arrest."
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"In vitro investigations indicated that therapeutic inhibition of USP1 induced the downregulation of ID1 and p-AKT, both previously reported as clinical indicators of ALL survival and prognosis [ 35 , [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"shRNA resistant wild-type USP1, but not USP1 C90S, suppressed E box driven reporter activity caused by USP1 knockdown, confirming that USP1 catalytic activity is required for bHLH dependent transcript[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Small molecule inhibitors of USP1 target ID1 degradation in leukemic cells."
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"Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells."
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"A doxycycline induced USP1 shRNA suppressed USP1 expression and reduced ID1 and ID2 in the xenografts."
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"Interestingly, USP1 has been described as an oncogene in Acute Myeloid leukaemia (AML) [30], and USP1 inhibition has been shown to reduce primary AML cell growth by promoting degradation of the ID1 protein and disrupting homologous recombination [36]."
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"Pimozide promoted the degradation of ID1 mediated by USP1, which led to interference in cancer progression."
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"small-molecule inhibitors of USP1 promote the degradation of inhibitor of DNA binding 1 (ID1), and are cytotoxic to leukemic cells [XREF_BIBR]."
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"Moreover, depletion of USP1 by siRNA promoted ID1 degradation in K562 cells (XREF_SUPPLEMENTARY)."
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"USP1 deubiquitylates inhibitors of DNA binding (ID) proteins and promotes stem cell-like characteristics in osteosarcoma (39), while USP1 inhibitor pomozide promotes ID1 degradation and inhibits leukemic cells growth (40)."
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